载姜黄素羟基磷灰石纳米颗粒富集去除有机污染物和抑制双种生物膜的形成

Govindasamy Palanisamy, Jin-Hyung Lee, Jintae Lee
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摘要

金黄色葡萄球菌和鲍曼不动杆菌对抗菌剂的耐药性导致慢性感染,因此从废水中去除污染物对于环境修复至关重要。去除废水中的有害污染物,抑制生物膜的形成是环境修复的重要内容。本研究利用原位沉淀技术有效构建了具有生物相容性的姜黄素负载羟基磷灰石纳米颗粒(curp - hap NPs)。利用各种分析表征技术对合成的NPs的结构、形态和化学成分进行了评价。高生物活性的天然姜黄素色素与羟基磷灰石NPs结合可保持其药理活性,并表现出姜黄素的缓释特征。采用结晶紫染色技术对金黄色葡萄球菌和鲍曼不动杆菌单种和混合双种的抗菌膜活性进行了评价。结果表明,cu - hap NPs对金黄色葡萄球菌、鲍曼不动杆菌和混合双种葡萄球菌具有良好的抑菌活性,抑菌效率分别为76.7%、85.6和68.8%。此外,cu - hap NPs对刚果红染料的吸附率约为95.6%。Cur-HAp可一次吸收高达112.4 mg/g的染料。负ΔG值(- 1.372 kJmol - 1)表明染料吸附在Cur-HAp上是自发可行的。Langmuir吸附等温线和拟二阶吸附方程对cu - hap NPs的拟合效果最好。因此,Cur-HAp NPs的持续药物释放行为是对抗抗生素膜活性和染料去除能力的有希望的候选物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Curcumin-loaded hydroxyapatite nanoparticles for enriched removal of organic pollutants and inhibition of dual-species biofilm formation
The resistance of staphylococcus aureus and Acinetobacter baumannii to antimicrobial agents results in chronic infections, making removing contaminants from wastewater essential for environmental remediation. Removing hazardous pollutants from wastewater and inhibiting biofilm formation is important for environmental remediation. This study effectively built biocompatible curcumin-loaded hydroxyapatite nanoparticles (Cur-HAp NPs) using a simple in-situ precipitation technique. Various analytical characterization techniques were used to evaluate the structural, morphological, and chemical composition of the synthesized NPs. Combining a highly bioactive natural curcumin pigment with hydroxyapatite NPs could maintain its pharmacological activity and exhibit a sustained release profile of curcumin. The antibiofilm activities against single and mixed dual species of S. aureus and A. baumannii were evaluated using crystal violet staining techniques. Excellent antibiofilm activities were demonstrated by Cur-HAp NPs against S. aureus, A. baumannii, and mixed dual species, with respective efficiency percentages of 76.7, 85.6, and 68.8 % inhibition upon treatment, respectively. In addition, Cur-HAp NPs demonstrated excellent dye adsorption against Congo red dye by approximately 95.6 %. Cur-HAp could absorb up to 112.4 mg/g of dye at a time. Negative ΔG value (−1.372 kJmol−1) indicates the spontaneous and feasible dye absorption onto Cur-HAp. The Langmuir adsorption isotherm and pseudo-second-order equation provided the best fit for the Cur-HAp NPs. Therefore, the sustained drug release behavior of Cur-HAp NPs is a promising candidate for combatting antibiofilm activity and dye removal capacity.
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