伊拉克2型糖尿病患者的动脉粥样硬化指数及其与心血管疾病风险的关系

Hind Shakir Ahmed, Melak Saleh Mohammed
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引用次数: 0

摘要

背景:糖尿病是动脉粥样硬化性心血管疾病的重要危险因素,也是导致死亡的重要原因。血脂异常通常与2型糖尿病相关,血浆动脉粥样硬化指数是预测动脉粥样硬化和冠心病风险的重要指标。目的:探讨2型糖尿病患者血脂与心血管疾病的相关性。患者和方法:本临床研究于2022年10月至2023年2月在巴格达教学医院/巴格达医疗城进行。本研究招募了60例2型糖尿病患者:30例有心血管疾病患者,30例无心血管疾病患者。他们的年龄在40-55岁之间。另外选择30名健康个体作为对照组。结果:合并心血管疾病的糖尿病患者的血糖和血脂调查结果明显高于无心血管疾病的糖尿病患者和对照组。目前的结果显示,糖尿病合并心血管疾病患者的血脂比率较高。结果还显示,合并心血管疾病的糖尿病患者非高密度脂蛋白胆固醇水平较高(241.8±12.24 mg/dL),而无心血管疾病和对照组的非高密度脂蛋白胆固醇水平分别为(150.1±7.12和68.9±5.1 mg/dL)。糖尿病合并心血管疾病患者血浆动脉粥样硬化指数分别为(0.8±0.09)、(0.7±0.03)、(0.2±0.08)。在合并和不合并心血管疾病的糖尿病患者中,血浆动脉粥样硬化指数与人体测量因子、血糖和脂质谱及其比值有显著相关性。结论:本研究结果证实脂质指标是血糖控制的危险指标,比传统因素具有更高的预后价值。因此,血浆非高密度脂蛋白胆固醇和动脉粥样硬化指数可作为血糖控制的重要预测指标。收稿日期:2023年2月录用日期:2023年5月发表日期:2023年10月
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Atherogenic Indices in Type 2 Diabetic Iraqi Patients and Its Association with Cardiovascular Disease Risk
Background: Diabetes is a serious risk factor for atherosclerotic cardiovascular disease and an important cause of mortality. Dyslipidemia is commonly related to type 2 diabetes, and the atherogenic index of plasma is a strong marker to predict the risk of atherosclerosis and coronary heart disease. Objective: To study the association of atherogenic indices lipids in type 2 diabetic Iraqi patients with cardiovascular disease. Patients and Methods: This clinical study was conducted at Baghdad Teaching Hospital/ Medical City-Baghdad from October 2022 to February 2023. Sixty type 2 diabetic patients were recruited for this study: 30 patients with cardiovascular disease and 30 without cardiovascular disease. Their ages were between 40-55 years. Another 30 healthy individuals were selected as a control group. Results: There were considerable rises in glycemic and lipid investigations in diabetic patients with cardiovascular disease compared to those without cardiovascular disease and the control group. The present results show higher levels of lipid ratios in diabetic patients with cardiovascular disease. The results also revealed high levels of non-high-density lipoprotein cholesterol for diabetic patients with cardiovascular disease (241.8±12.24 mg/dL) versus (150.1±7.12 and 68.9±5.1 mg/dL) for those without cardiovascular disease and the controls group respectively. The atherogenic index of plasma in diabetic patients with cardiovascular disease compared to diabetic and healthy control groups were (0.8±0.09) versus (0.7±0.03 and 0.2±0.08) respectively. There was a significant correlation between the atherogenic index of plasma and anthropometric factors, glycemic and lipid profile with their ratios in diabetic patients with and without cardiovascular disease. Conclusions: The results of this study confirm that the lipid indices are risk indicators of glycemic control with higher prognostic value than traditional factors. So, non-high-density lipoprotein cholesterol and atherogenic index of plasma can be used as a significant predictor of glycemic control. Received: Feb., 2023 Accepted: May, 2023 Published: Oct. 2023
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