临床病例报告:病灶内皮质激素在复发性气管狭窄中的应用。

Irene Lucía Torres Washima, Miguel Sebastián Nivelo Ávila, Marcos Andrés Aguirre Vintimilla, Jorge Andrés Torres Jerves
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摘要

背景:成人良性气管狭窄有三种病因:继发于延长插管、特发性和风湿病。与长时间插管相关的一种被描述为由于气囊对气管粘膜的持续压力引起的病变,这容易引起局部高炎症反应;因此,对这种反应进行调节治疗已被提议作为传统手术治疗的替代方法。迄今为止,还没有一种治疗方法被定义为黄金标准;开放和内窥镜治疗都是可行的,在最后描述的治疗中,一种选择是局部注射皮质类固醇。病例报告:这是一名47岁的女性,有长期机械通气史;几个月后,她被诊断为气管狭窄,最初接受扩张和支架置入术治疗,随后出现并发症(支架移位,因呼吸窘迫而再次介入治疗)。患者因呼吸困难、喘鸣、咳嗽、口臭和全身不适求医,经纤维支气管镜检查发现严重气管狭窄(98%)。进化:使用刚性支气管镜,取出支架,进行扩张,我们给药一次病灶内皮质类固醇,有良好的即时反应;此外,还进行了为期两天的肌内皮质类固醇治疗。手术后6个月,患者没有复发,气管狭窄稳定在30%。结论:在进行了文献回顾以及我们与患者的成功经验之后,我们同意现有文献,认为这种新的治疗方案适合其应用,尽管我们认识到需要更大规模的研究来定义精确的适应症和最佳方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Reporte de caso clínico: aplicación de corticoide intralesional en estenosis traqueal recidivante.
BACKGROUND: Benign tracheal stenosis in adults has three etiologies: secondary to prolonged intubation, idiopathic, and rheumatologic. The one associated with prolonged intubation has been described as a lesion due to the persistent pressure of the balloon on the tracheal mucosa, which predisposes to a regional hyperinflammatory response; for that reason, modulating treatments for this response have been proposed as an alternative to classical surgical treatment. To date there is no treatment defined as Gold-Standard; both open and endoscopic treatments are practiced, among the last described, an option is intralesional corticosteroids injection. CASE REPORT: This is a 47-year-old woman with a history of prolonged mechanical ventilation; months later she was diagnosed with tracheal stenosis, initial treated with dilation and stent placement, with subsequent complications (stent migration, reinterventions due to respiratory distress). The patient sought medical attention due to dyspnea, stridor, productive cough, halitosis and general malaise, finding severe tracheal stenosis (98%) by flexible fiberoptic bronchoscopy. EVOLUTION: Using rigid bronchoscopy, the stent was removed, dilation was performed, and we administered intralesional corticosteroid for one time, with a good immediate response; in addition, a course of intramuscular corticosteroids was administered for two days. Six months after the procedure, the patient remained without recurrences, with a stable tracheal stenosis of 30%. CONCLUSION: After the bibliographic review carried out, as well as the successful experience we had with the patient, we agree with the available literature that this new treatment option is adequate for its application, although we recognize that larger studies are required to define the precise indications and an optimal protocol for its establishment.
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