FORMULATION AND IN VITRO EVALUATION OF IMMEDIATE RELEASE SOFTGEL OF NAPROXEN SODIUM

www.johronline.com 286 | P a g e For Correspondence: sarangi.dipu@gmail.com. Received on: October 2018 Accepted after revision: November 2018 DOI: 10.30876/JOHR.6.4.2018.286-296 Introduction: Soft gelatin capsules or soft gels are a single-unit solid dosage form, consisting of a liquid or semi-solid fill enveloped by a onepiece sealed elastic outer shell. The amount of drug or extract together with adjuvant is enclosed within a globular, oval or other shape of a soft shell. Soft gelatin capsules offer the possibility of delivering a liquid in a solid oral dosage form. The soft gel can contain the active ingredient in solution, suspension or emulsion which will inherently lead to better absorption of the active ingredient as compared with delivery in a tablet or as a powder . Advantages: Increased the Rate of Absorption of Drugs: This has been achieved by using a drug solution matrix in a soft gel formulation where by absorption is significantly faster than from other solid oral dosage forms, such as compressed tablets. While absorption of a poorly soluble drug from a tablet formulation is rate-limited by the need for disintegration into Abstract: Oral drug delivery has been known for decades as th e most widely utilized route of administered among all the routes that have been em ployed for the systemic delivery of drug via various pharmaceutical products of different dosage forms. The reasons that the oral route achieved such popularity may be in part attributed to its ea se of administration and the belief that oral administration of the drug is well absorbed. One su ch area of research is design of Softgel technology . Softgel technology is one of the most attractive an d promising approach for increasing oral bioavailability by means of increasing solubility o f the poorly soluble drug. Naproxen Sodium is one of the most important Non-steroidal anti-inflammato ry agents used in the treatment of acute to chronic pains, inflammation and it belongs to BCS class-II drug so as to increase its aqueous solubility for enhancing the bioavailability, it is formulated as a liquid filled soft gelatin capsules.