全基因组测序确定中国南方哺乳仔猪腹泻的起源

2019 IEEE 7th International Conference on Bioinformatics and Computational Biology ( ICBCB) Pub Date : 2019-03-01 DOI:10.1109/ICBCB.2019.8854647

Jie Li, Jiating Qian, Xuanxuan Mao, C. Xue, Yongchang Cao

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引用次数: 0

摘要

2017年，中国南方发生了哺乳仔猪严重腹泻，并发现了一种名为猪肠道甲型冠状病毒(PEAV)的新型猪冠状病毒。本文报道了PEAV全基因组测序、组装和分析的详细过程。GDS04与未经重组的HKU2株的S蛋白具有87%的氨基酸同源性，其S蛋白的受体结合结构域存在20个氨基酸差异，提示GDS04可能是来自蝙蝠样冠状病毒的一种新的突变病毒，可能是导致中国南方猪群最近腹泻流行的原因。

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Whole-Genome Sequencing to Determine Origin of Diarrhea in Suckling Piglets in Southern China

Severe diarrhea in suckling piglets occurred in southern China in 2017 and a new porcine coronavirus, named as porcine enteric alphacoronavirus (PEAV), was identified. Here we reported a detailed process to sequence, assemble and analyze the whole genome of PEAV. GDS04 has 87% amino acid identity comparing to the S proteins of the HKU2 strains without recombination, and their receptor-binding domains in S protein differ at 20 amino acids, suggesting that GDS04 could be a new mutant virus from bat-like CoVs and responsible for the most recent diarrhea endemic in pig herds in southern China.

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2019 IEEE 7th International Conference on Bioinformatics and Computational Biology ( ICBCB)

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