主题演讲5:基于神经可塑性的策略应用于延迟发病和治疗精神和神经疾病

M. Merzenich
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摘要

Merzenich博士的研究兴趣包括体感觉和听觉神经系统的功能组织;学习诱发的皮层可塑性的神经学基础和规则以及语言、阅读、记忆、注意力、认知控制和运动方面的发育和获得性损伤的神经学起源和修复。他的研究团队广泛地模拟了a)脑损伤和中风后引起的大脑变化;B)由于扭曲的经验历史导致获得性损伤、精神病和成瘾;c)在衰老过程中导致病理性神经退化。所有这些都被研究为开发基于大脑可塑性的医学治疗方法的平台,以治疗人类的这些疾病。Merzenich博士领导的一个研究小组创造了一种广泛商业应用的人工耳蜗(Advanced Bionics’Symbion)。1996年,他与他人共同创立了Scientific Learning公司,致力于为学龄儿童提供语言、阅读、注意力和认知障碍的补救疗法。它的项目已经帮助了500多万儿童。2002年,他与人共同创立了Posit Science,该公司生产并提供计算机传送疗法,用于帮助老年人、精神障碍者和脑损伤人群。2009年,他与人共同创立了脑可塑性研究所(Brain Plasticity Institute),这是一家研究公司,专注于为患有严重神经损伤的儿童和成人开发新的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Keynote lecture 5: Neuroplasticity-based strategies applied to delay onsets of-and to treat-psychiatric and neurological disorders
Dr. Merzenich's research interests have included the functional organization of the somatosensory and auditory nervous systems; the neurological bases of - and rules governing-learning-induced cortical plasticity; and the neurological origins of and remediation of developmental and acquired impairments in language, reading, memory, attention, cognitive control, and movement. His research teams have extensively modeled changes induced in the brain a) following brain injury and stroke; b) resulting from distorted experiential history leading to acquired impairments, psychotic illness and addiction; and c) contributing to pathological neurological regression in aging. All have been studied as platforms for developing brain plasticity-based medical therapeutics to treat those conditions in human populations. Dr. Merzenich led a research team that created a widely commercially applied cochlear implant (Advanced Bionics' Symbion). In 1996, he co-founded Scientific Learning, a company dedicated to delivering remedial therapies to address language, reading, attention, and cognitive impairments in school age children. Its programs have been applied to help more than 5 million children. In 2002, he co-founded Posit Science, which produces and delivers computer-delivered therapies applied to help aging, psychiatrically-impaired, and brain-injured populations. In 2009, he co-founded the Brain Plasticity Institute, a research company focused on developing new treatment strategies for children and adults with severe neurological impairments.
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