Effect of acute and chronic administration of hot water extract of P. Americana on some metabolic parameters in diabetic rats

The challenge of comorbid diseases and especially their management. Posing greater challenge are phytomedical approach without proper scientific testing and more also paucity of modern equipment for research and funding. The need to authenticate medicinal herbs used in the management of Diabetes Mellitus (DM) as one of the common metabolic diseases becomes imperative. This study aimed at evaluating the effect of acute and chronic administration of hot water extract of P. americana on some metabolic parameters in diabetic rats. Thirty young adult healthy male albino rats (wistar strain) weighing between 205-251 g were made diabetic by administration of 80 mg/kg streptozotocin (STZ). The animals were divided into two equal groups of 15 rats each, singly placed in metabolic cages for the acute and chronic treatments studies. The rats were further divided into three groups of 5 animals each and treated with different concentrations of stem-bark hot water extract of Persea americana (HWE-PA) and distilled water while the body weight, food intake, faecal output, water intake and urine output were measured and recorded daily for a period of 5 days for the acute and 28 days for the chronic treatments. Results showed a higher percentage change in body weights, higher food intake and faecal output and lower values in water intake and urine output in both acute and chronic administration of HWE-PA to STZ-induced hyperglycaemic rats compared to the control groups. Both acute and chronic administration of Hot water extract of the stem-bark animals extracts of Persea americana (HWE-PA) presented antidiabetic activity STZ-induced hyperglycaemic rats as evident its ameliorating effect on the body weight, food intake, faecal output, water intake and urine output in STZ-induced hyperglycaemic rats, thus supports its phytomedicine use as an antidiabetic agent.