基于FPGA的基因组微阵列处理便携式远程应用

V. Rodellar, F. Diaz, Bogdan Belean, R. Malutan, B. Stetter, Pedro Gómez, Rafael Martínez, Eloy García, J. Peldez
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引用次数: 6

摘要

在生物医学工程的许多领域中,应用层面的可移植性、紧凑性和健壮性是一个重要的要求。基因组微阵列检测正在成为医学、生物学和药理学许多领域的常规探索。这些检测必须符合严格和繁琐的规程,这使得它们无法普遍适用于偏远地区或难以进入医院设施的情况,如船员、军事分遣队或不发达国家对孤立人口的关注。寻求解决办法,翻译复杂的勘探方法,因为这些方法可能意味着检测和治疗不同的遗传引起的疾病,并有助于将高标准的医学推广到这些情况。本文介绍了一种用于基因微阵列检测的手持便携式应用程序,该应用程序具有自主和鲁棒性等重要优点。该系统基于CCD微阵列图像扫描和先进的图像处理软件,在FPGA的支持下进行鲁棒检测和读取。该平台是为独立使用和低重量和消耗而设计的,使其成为远程医疗应用的理想选择。还提供了在笔记本电脑中存储数据的设施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Genomic Microarray Processing on a FPGA for Portable Remote Applications
There are many fields in biomedical engineering where portability, compactness and robustness at the application level is an important requirement. Genomic microarray tests are becoming a routine exploration in many areas of medicine, biology and pharmacology. These tests have to fulfill strict and cumbersome protocols which prevent them from being universally applied in remote areas or situations where access to hospital facilities is difficult, as in the case of ship crews, military detachments or in the attention to isolated populations in underdeveloped countries. Seeking for solutions to translate sophisticated exploration methods as these may imply the detection and treatment of different genetic-induced illnesses and help in extending high standard medicine to these situations. In the present paper a hand-held portable application to inspect genetic microarrays is presented, which may be used in the field with important advantages on autonomy and robustness. The system is based on CCD microarray image scanning plus advanced image processing software for robust detection and reading supported by an FPGA. The platform is conceived for stand-alone use and low weight and consumption, making it ideal for applications in telemedicine. Facilities for data storage in a laptop are also provided.
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