{"title":"Rorc2，一个新的th17特异性治疗靶点，用于治疗病毒感染","authors":"Ancuța Petronela","doi":"10.54044/rami.2021.03.01","DOIUrl":null,"url":null,"abstract":"[...]viral reservoir persist in long-lived memory Th17 cells of people living with HIV (PLWH) receiving viral-suppressive antiretroviral therapy (ART) and represent a major barrier against HIV eradication (reviewed in [1, 4]). [...]these RORC2 inhibitors may interfere with RORC2-gouverned transcriptional program that is associated with the expression of multiple HIV permissiveness factors in Th17 cells. [...]given Th17 pathogenicity during SARS-CoV-2 infection, when they promote the massive infiltration of inflammatory neutrophils in the lungs [3], there is a need to test RORC2 inhibitors in animal models.","PeriodicalId":237638,"journal":{"name":"Romanian Archives of Microbiology and Immunology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"RORC2, A NEW TH17-SPECIFIC THERAPEUTIC TARGET TO TREAT VIRAL INFECTIONS\",\"authors\":\"Ancuța Petronela\",\"doi\":\"10.54044/rami.2021.03.01\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"[...]viral reservoir persist in long-lived memory Th17 cells of people living with HIV (PLWH) receiving viral-suppressive antiretroviral therapy (ART) and represent a major barrier against HIV eradication (reviewed in [1, 4]). [...]these RORC2 inhibitors may interfere with RORC2-gouverned transcriptional program that is associated with the expression of multiple HIV permissiveness factors in Th17 cells. [...]given Th17 pathogenicity during SARS-CoV-2 infection, when they promote the massive infiltration of inflammatory neutrophils in the lungs [3], there is a need to test RORC2 inhibitors in animal models.\",\"PeriodicalId\":237638,\"journal\":{\"name\":\"Romanian Archives of Microbiology and Immunology\",\"volume\":\"1 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-09-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Romanian Archives of Microbiology and Immunology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.54044/rami.2021.03.01\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Romanian Archives of Microbiology and Immunology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.54044/rami.2021.03.01","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
RORC2, A NEW TH17-SPECIFIC THERAPEUTIC TARGET TO TREAT VIRAL INFECTIONS
[...]viral reservoir persist in long-lived memory Th17 cells of people living with HIV (PLWH) receiving viral-suppressive antiretroviral therapy (ART) and represent a major barrier against HIV eradication (reviewed in [1, 4]). [...]these RORC2 inhibitors may interfere with RORC2-gouverned transcriptional program that is associated with the expression of multiple HIV permissiveness factors in Th17 cells. [...]given Th17 pathogenicity during SARS-CoV-2 infection, when they promote the massive infiltration of inflammatory neutrophils in the lungs [3], there is a need to test RORC2 inhibitors in animal models.
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