肥胖与非肥胖患者血清半乳糖凝集素-3水平的相关性分析

N. Nurjannah, Nurahmi Nurahmi, L. B. Kurniawan
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引用次数: 0

摘要

全世界每年有340多万人死于超重和肥胖。肥胖是一种慢性促炎疾病,其特征是脂质和脂肪组织增加,导致异位脂肪积累,促炎细胞因子水平升高。肥胖导致半乳糖凝集素-3表达的进行性增加,特别是在实验动物的内脏和皮下脂肪组织中。半乳糖凝集素-3在肥胖中上调,被定义为一种能引起胰岛素抵抗的促炎分子。本研究旨在分析肥胖和非肥胖受试者半乳糖凝集素-3水平的差异。这是一项横断面研究,共有80名受试者。该研究于2022年8月进行。研究对象根据身体质量指数(BMI)分为肥胖和非肥胖两组。半乳糖凝集素-3测定采用酶联免疫吸附试验(ELISA)法。统计检验采用Mann-Whitney检验和Spearmen rho;如果p值<0.05,则检验结果具有显著性。这些样本被分为肥胖组和非肥胖组,每组40人。肥胖组半乳糖凝集素-3水平为0.9±0.36 ng/mL,显著高于非肥胖组的0.43±0.11 ng/mL,差异有统计学意义(p<0.001)。半凝集素-3水平与BMI呈正相关(r=0.866, p<0.001)。血清半凝集素-3水平与BMI呈正相关。BMI值越大,半乳糖凝集素-3水平越高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Correlation Analysis of Galectin-3 Serum Level in Obesity with and without Obesity
There are more than 3.4 million deaths every year in the world due to overweight and obesity. Obesity is a chronic proinflammatory condition marked by increased lipid and adipose tissues, leading to ectopic fat accumulation with increased levels of proinflammatory cytokines. Obesity causes a progressive increase in galectin-3 expression, especially in visceral and subcutaneous adipose tissue in experimental animals. Galectin-3 is upregulated in obesity and is defined as a proinflammatory molecule that can cause insulin resistance. This study aims to analyze differences in galectin-3 levels between obese and non-obese subjects. This was a cross-sectional study, using a total of 80 subjects. The study was conducted throughout August 2022. The samples were grouped into obese and non-obese based on Body Mass Index (BMI). The galectin-3 measurement used the Enzyme-Linked Immunosorbent Assay (ELISA) method. Statistical tests used the Mann-Whitney test and Spearmen rho; the test results were significant if the p-value <0.05. The samples were divided into obese and non-obese groups, each group had 40 people. Galectin-3 levels in the obese group were 0.9±0.36 ng/mL significantly higher than the non-obese group’s 0.43±0.11 ng/mL, (p<0.001). There was a strong positive correlation between levels of galectin-3 and BMI, (r=0.866, p<0.001). There is a positive correlation between serum galectin-3 levels and BMI. The greater value of the BMI, the higher levels of galectin-3.
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