真核生物DNA切除修复的分子遗传学。

IF 3.5 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1990-10-01

J H Hoeijmakers, D Bootsma

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引用次数: 0

摘要

DNA修复在预防癌变和突变中起着关键作用。DNA修复缺陷与各种人类遗传疾病有关，这些疾病使受影响的个体易患癌症。本文回顾了我们目前对主要DNA修复系统之一——核苷酸切除修复途径的理解，特别强调了酵母和培养的哺乳动物细胞的分子遗传分析中出现的新发现。

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Molecular genetics of eukaryotic DNA excision repair.

DNA repair plays a key role in the prevention of carcinogenesis and mutagenesis. Defective DNA repair has been implicated in various human hereditary disorders that predispose affected individuals to cancer. This article reviews our current understanding of one of major DNA repair systems--the nucleotide excision repair pathway--with special emphasis on the novel findings that have emerged from molecular genetic analysis of yeast and cultured mammalian cells.

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来源期刊

Cancer cells (Cold Spring Harbor, N.Y. : 1989)

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