THE rs7903146 SNP Of TCF7L2 GENE AND ITS ASSOCIATION WITH THE METABOLIC SYNDROME A REVIEW

Objective: To Conduct a systematic review of the literature in order to clarify and discuss the effects of SNP rs7903146 in the TCF7L2 gene and predisposition to Metabolic Syndrome (MS) modulation by dietary factors such variant. Methods: We performed a review of the literature in a systematic way from original studies between 2000 and 2013, found in Medline, PubMed, Wiley library, SciELO, ScienceDirect, Springer link, The University of Adelaide, DeepDyve, Cambridge journals. Results: The clinical trials reported in this study indicated a significant correlation between the risk allele of rs7903146 polymorphism and pathophysiological characteristics of MS, with the most consistent findings with changes in glucose homeostasis, insulin metabolism and atherogenic dyslipidemia for each study population. Conclusions: This review highlights the scientific evidence for rs7903146 polymorphism as one of the etiologic basis for MS. However, demonstrates the need for greater standardization of investigations, to reduce possible population variables with potential influence on the results, such as environmental factors and genetic heterogeneity.