卡齐纳市部分糖浆和悬浮液微生物污染评价

A. M
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引用次数: 0

摘要

本研究试图评价在卡齐纳市出售的一些糖浆和悬浮液的微生物污染。这项研究于2021年11月至2022年1月在卡齐纳大学生物科学实验室进行。采用标准培养和生化方法对尼日利亚不同制药工业生产的18种不同类型的口服液药物(9种糖浆和9种悬浮液)进行微生物学检查。所有样品均被总活菌和真菌污染,最大负荷为103 cfu/ml,所有样品均超过美国药典(USP)限值(<102 cfu/ml)。而存在的细菌包括;在几乎所有样品中均发现大肠杆菌、沙门氏菌和志贺氏菌,其中11个糖浆和悬浮液样品中发现大肠杆菌,3个悬浮液样品中发现沙门氏菌,8个悬浮液中发现志贺氏菌。口服液样品中微生物的存在可能解释了患病儿童的治疗复杂性。因此建议对这类药物进行常规的微生物学研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of Microbiological Contamination of Some Selected Syrups and Suspentions Solid in Katsina Metropolis
Presented study attempted to evaluate the Microbiological contamination of some selected syrups and suspensions sold in Katsina metropolis. This study was conducted in Biological sciences laboratory Al-qalam University Katsina between the months of November 2021 to January 2022. Eighteen different types of oral liquid drugs (9 syrups and 9 suspensions) manufactured in different pharmaceutical industries of Nigeria were microbiologically examined using standard cultural and biochemical methods. All the samples were found to be contaminated with total viable bacteria and fungi with a maximum load of 103 cfu/ml among all samples were exceeded the United States Pharmacopeia (USP) limit (<102 cfu/ml). While the presences bacteria including; E.coli, Salmonella spp., Shigella spp., were found to be presences in almost all samples, (the former of E.coli in 11 syrups and suspension samples, the Salmonella spp. in 3 suspension samples and the Shigella spp. In 8 suspensions). Existence of microorganisms in the oral liquid samples might explain the treatment complicacy of the diseased children. A routine microbiological study of such drugs is thus suggested.
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