多准则决策在生物链接选择中的应用

Lily Rohrbach, P. Huebner
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引用次数: 0

摘要

生物打印是组织工程和再生医学(TERM)中一个快速兴起的研究领域,其中活细胞被嵌入溶液(称为生物链接)中,并3D打印成解剖学相关的几何形状,用于体内植入;这使得原生组织再生得更好更快。目前大多数研究都是研究生物墨水的力学、流变和生物学特性,但很少有方法根据一套以应用为中心的相关标准对生物墨水进行数学排序。在本研究中,我们开发了一种用于肌肉骨骼组织工程的生物墨水评估的通用方法,使用多标准决策(MCDM)工具,包括分析层次分析法(AHP)、简单相加加权法(SAW)和理想溶液相似性优先排序技术(TOPSIS)。gelma -海藻酸盐、dECM、peg -纤维蛋白原、胶原蛋白和透明质酸均采用细胞活力、剪切变薄、可打印性、降解率、储存能力和成本等标准进行评估。结果包括一个比较矩阵,显示了每个标准的相对重要性,以及从每种排名方法中选择的每个生物链接的排名。未来的研究应该集中在建立所提出的模型上,考虑更大的生物墨水替代品和标准集,以证明模型处理大型数据集的能力,以及用更多关于生物墨水特性的最新数据更新评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Application of Multi-Criteria Decision Making in Bioink Selection
Bioprinting is a rapidly emerging area of study within Tissue Engineering and Regenerative Medicine (TERM) where live cells are be embedded in a solution (referred to as a bioink) and 3D printed into anatomically relevant geometries for in vivo implantation; this allows native tissues to regenerate better and faster. Most current research investigates the mechanical, rheological, and biological properties of bioinks, but few methods have been proposed to mathematically rank bioinks based on a set of application-focused, relevant criteria. In this study, we develop a general methodology to evaluate bioinks for the purpose of musculoskeletal tissue engineering, using multi-criteria decision making (MCDM) tools, including analytical hierarchy process (AHP), simple additive weighting (SAW), and technique for order of preference by similarity to ideal solution (TOPSIS). GelMA-alginate, dECM, PEG-fibrinogen, collagen, and HA were all evaluated using the criteria of cell viability, shear thinning, printability, degradation rate, storage ability, and cost. Results include a comparison matrix showing the relative importance of each criterion as well as a ranking of each selected bioink from each ranking method. Future research should focus on building upon the proposed model by considering a larger set of bioink alternatives and criteria to demonstrate the model’s ability to handle large datasets, as well as updating evaluations with more current data regarding the properties of bioinks.
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