[系统性硬皮病患者自然杀伤细胞活性紊乱机制的研究]。

IF 0.5 Q4 DERMATOLOGY

Przeglad dermatologiczny Pub Date : 1990-07-01

L Rudnicka, S Majewski, M Błaszczyk, A Skiendzielewska, B Makieła

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引用次数: 0

摘要

对90例系统性硬皮病(SSc)不同亚群患者外周血单个核细胞(PBMC) NK活性进行了评价。以K-562为靶细胞的NK活性在弥漫性硬皮病患者中被发现显著降低，但与动脉硬化症患者的健康对照没有差异。NK活性测定的最低值是在最广泛的皮肤受累和严重的内脏改变的患者中获得的。在细胞毒性实验中加入SSc患者PBMC(50:1)后，健康供者PBMC的NK活性显著降低，但不受患者血清的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

[Studies of the mechanism of disorders of the natural killer cell activity in patients with systemic scleroderma].

The NK activity of peripheral blood mononuclear cells (PBMC) was evaluated in 90 patients with various subsets of systemic scleroderma (SSc). The NK activity, as performed with K-562 as target cell, was found to be significantly lowered in patients with diffuse scleroderma, but did not differ from the healthy control in patients with acrosclerosis. The lowest values in the NK activity assay were obtained in patients with most extensive skin involvement and severe internal organ changes. The NK activity of healthy donors' PBMC was significantly decreased by addition of SSc patients PBMC (50:1) to the cytotoxicity assay, but was not influenced by the patients sera.

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来源期刊

Przeglad dermatologiczny DERMATOLOGY-

CiteScore

0.80

自引率

14.30%

发文量

审稿时长

12 weeks

期刊介绍： Przegląd Dermatologiczny (ang. Dermatological Review) is a bimonthly magazine of the Polish Dermatological Association. It publishes original (clinical and experimental) papers, review papers, care reports, reports from congresses, reviews of books, announcements, letters to the editor and special papers (requested by the editors), concerning selected dermatological and interdisciplinary issues. Papers sent to the editor are reviewed.