BIOPHARMACEUTICAL ASPECTS OF CHOOSING THE BASIS OF PENCILS OF MEDICINAL WOUND-HEALING ACTION

Damage to the skin is quite common in everyday life of a person and represents a loss of the integrity of the protective barrier of the skin, which can create conditions for the development of a local inflammatory process, as well as for the penetration of pathogens of various diseases into the human body. In order to more quickly restore the damaged area of the skin, it is important to accelerate wound healing through the use of combined drugs, including antiseptics and biologically active substances of natural origin, stimulating the natural local regenerative process. One of such rational combinations is the combination of chlorhexidine bigluconate and Japanese Sophora fruit liquid extract in the composition of the wound-healing preparation. Medicinal sticks are presented as the most rational dosage form for a wound-healing drug of the specified composition. The application of this dosage form to the treated surface leads to the formation of a thin, firmly adhering film, which evenly releases the active substances and protects the wound from external influences. The indicated positive properties of medicinal pencils are achieved due to the selection of a rational component composition of excipients with a set of necessary characteristics, among which the most significant is the ability to provide optimal release of active substances. In this regard, the purpose of this study was to conduct comparative biopharmaceutical studies to optimize the component composition of medicinal pencils with wound healing action containing chlorhexidine bigluconate and liquid extract of sophora fruit. The objects of research were Japanese Sophora fruits harvested in 2020 in the Krasnodar Territory that meet the requirements of regulatory documents; substance-solution of chlorhexidine bigluconate 20%; auxiliary substances of lipophilic and hydrophilic nature: solid paraffin, beeswax, cocoa butter, anhydrous lanolin, polyethylene oxide-400, polyethylene oxide-1500. To assess the degree of release of active substances from experimental compositions, the method of diffusion into agar was used, based on the diffusion of active substances from the dosage form into an agar gel containing a solution of ferric chloride as an indicator. It was found that the most suitable combination of auxiliary components of the dosage form, providing the best release of active substances, is a combination including solid paraffin (20 parts), beeswax (20 parts), anhydrous lanolin (20 parts), polyethylene oxide-1500 (10 parts), polyethylene oxide-400 (20 parts).