柔性四极生物阻抗传感器的表征和建模及肠道组织测量

2019 IEEE 19th International Conference on Bioinformatics and Bioengineering (BIBE) Pub Date : 2019-10-01 DOI:10.1109/BIBE.2019.00129

P. Kassanos, F. Seichepine, Guang-Zhong Yang

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引用次数: 5

摘要

电生物阻抗是一种很有前途的体内组织表征方法。为了开发优化的电子仪器，了解生物阻抗传感器和目标组织的电特性是必不可少的。本文介绍了一种利用柔性印刷电路(FPC)技术制备的肠腔内粘膜缺血评估四极生物阻抗传感器的特性。电极阻抗分别在盐水溶液中单独和成对测量，并提出了等效电路。传感器随后在盐水溶液中的四极阻抗测量中进行评估，以实验提取装置的几何细胞常数。最后，介绍了猪肠腔内组织的体外四极测量。电极阻抗为145±42 kΩ，而组织阻抗在1.77 ~ 2.06 kΩ之间。这项工作允许设计下一代优化的CMOS仪器，用于特定应用和传感器的植入式生物阻抗测量。

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Characterization and Modeling of a Flexible Tetrapolar Bioimpedance Sensor and Measurements of Intestinal Tissues

Electrical bioimpedance is a promising in vivo tissue characterization method. To develop optimized electronic instrumentation, knowledge of the electrical characteristics of the bioimpedance sensor and the targeted tissue are essential. This paper presents novel results from the characterization of a tetrapolar bioimpedance sensor for intestinal intraluminal mucosal ischemia assessment fabricated using flexible printed circuit (FPC) technology. The electrode impedance is measured individually and in pairs in saline solutions and equivalent circuits are proposed. The sensor is subsequently assessed in tetrapolar impedance measurements in saline solutions to extract experimentally the geometrical cell constant of the device. Finally, in vitro tetrapolar measurements from porcine intraluminal intestinal tissue are presented. The electrode impedance was found to be 145 ± 42 kΩ, while the tissue between 1.77 and 2.06 kΩ at 20 Hz. This work allows the design of next generation optimized CMOS instrumentation for implantable bioimpedance measurements for the particular application and sensor.

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2019 IEEE 19th International Conference on Bioinformatics and Bioengineering (BIBE)

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