{"title":"DNA适体对透析相关淀粉样变性的治疗潜力","authors":"Y. Motomiya","doi":"10.31579/2834-5142/041","DOIUrl":null,"url":null,"abstract":"β2m is a precursor protein of the dialysis-related amyloidosis (DRA) and β2m lacking the N-terminal six residues of the mature protein (ΔN6β2m) is a one of amyloidogenic variant of β2m. In the previous study, we had showed an unfolding in the C-terminal of ΔN6β2m using the specific monoclonal antibody for ΔN6β2m. We had also reported firstly an aptamer specific for ΔN6β2m. ΔN6β2m-aptamers specifically and tightly bound to ΔN6β2m and inhibited fibril formation. These results suggest the potential of ΔN6β2m-aptamers as reagents for therapeutic tools to prevent amyloid deposits in dialysis patients.","PeriodicalId":382890,"journal":{"name":"International Journal of Clinical Nephrology","volume":"29 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Therapeutic Potential of DNA Aptamer for Dialysis-Related Amyloidosis\",\"authors\":\"Y. Motomiya\",\"doi\":\"10.31579/2834-5142/041\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"β2m is a precursor protein of the dialysis-related amyloidosis (DRA) and β2m lacking the N-terminal six residues of the mature protein (ΔN6β2m) is a one of amyloidogenic variant of β2m. In the previous study, we had showed an unfolding in the C-terminal of ΔN6β2m using the specific monoclonal antibody for ΔN6β2m. We had also reported firstly an aptamer specific for ΔN6β2m. ΔN6β2m-aptamers specifically and tightly bound to ΔN6β2m and inhibited fibril formation. These results suggest the potential of ΔN6β2m-aptamers as reagents for therapeutic tools to prevent amyloid deposits in dialysis patients.\",\"PeriodicalId\":382890,\"journal\":{\"name\":\"International Journal of Clinical Nephrology\",\"volume\":\"29 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-11-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Clinical Nephrology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.31579/2834-5142/041\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Clinical Nephrology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31579/2834-5142/041","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The Therapeutic Potential of DNA Aptamer for Dialysis-Related Amyloidosis
β2m is a precursor protein of the dialysis-related amyloidosis (DRA) and β2m lacking the N-terminal six residues of the mature protein (ΔN6β2m) is a one of amyloidogenic variant of β2m. In the previous study, we had showed an unfolding in the C-terminal of ΔN6β2m using the specific monoclonal antibody for ΔN6β2m. We had also reported firstly an aptamer specific for ΔN6β2m. ΔN6β2m-aptamers specifically and tightly bound to ΔN6β2m and inhibited fibril formation. These results suggest the potential of ΔN6β2m-aptamers as reagents for therapeutic tools to prevent amyloid deposits in dialysis patients.
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