R. Judah Rajendran, Kannan Ramesh, Prasanth Hannah Ranjee
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A case report of Multi System Atrophy (MSA) with cross over features of Progressive Supranuclear Palsy (PSP)
Multi System Atrophy is a rare neurodegenerative, synucleinopathic disorder which progresses rapidly. It often presents with symptoms similar to Parkinsonism posing a diagnostic dilemma. It is an orphan disease with an annual incidence of 0.1 to 3 per 100,000, with many being revealed only on autopsy, following years of treatment for Parkinson’s disease. There are very few cases reported from India, possibly because diagnosis requires a high index of suspicion, coupled with a comprehensive knowledge of the disease in order to detect it early and prevent progression.
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