基于图嵌入的中药方剂草药群落检测

Gansen Zhao, Zijing Li, Xinming Wang, Weimin Ning, Xutian Zhuang, Jianfei Wang, Qiang Chen, Zefeng Mo, Bingchuan Chen, Huiyan Chen
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引用次数: 0

摘要

利用机器学习模型,许多研究人员正在探索从大型中医数据中挖掘有价值的信息。针对现有中药群落检测方法存在的灵活性差、可扩展性差、药材网络地图性能差、小粒度网络难以处理、检测结果平衡性差等问题,本文创新性地提出了一种基于图嵌入的中药群落检测新思路。这个想法主要有三个步骤。第一步是建立中药处方网络。第二步是将网络中的每个草本节点映射到草本向量。第三步,利用常用的向量聚类算法对网络进行划分,得到草本群落。第二步是本文的核心步骤。为了体现药材节点的一对一和一对多关系,本文提出了基于两种图嵌入方法的两种药材向量构建方法,分别是矩阵分解法和改进随机游走法。为了对实验结果进行评价,本文提出了模块化、平衡性、人工分析相结合的综合评价指标,并对相关门诊处方记录数据进行了实验。实验结果表明,本文提出的新型中药群落检测方法在评价指标上优于传统的中药群落检测算法,同时,本文提出的向量构建方法还可以发现潜在的新型中药群落,有助于方剂构建的创新。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Herb Community Detection from TCM Prescription Based on Graph Embedding
Taking advantage of machine learning models, many researchers are exploring to dig out valuable information in large Traditional TCM(TCM) data. In view of the problems of existing TCM herb community detection methods, including poor flexibility, poor extensibility, poor performance of the herb network map, the difficulty in handling the network with small granularity, and the poor balance of detection results, this paper innovatively proposes a new herb community detection idea based on Graph Embedding. This idea mainly has three steps. The first step is constructing the TCM prescription network. The second step is mapping every herb node in the network to herb vector. The third step is using common vector clustering algorithm to get herb communities by dividing the network. In this paper, the second step is the core step. In order to reflect one-to-one and one-to-many relationship of herb nodes, this paper proposes two herb vector construction methods based on two Graph Embedding methods, respectively are matrix decomposition method and improved random walk method. In order to evaluate the experiment results, this paper proposes a comprehensive evaluation metrics which combining modularity, balance, and manual analysis and conducts experiments on relevant outpatient prescription record data. Experimental results show that the new herb community detection methods proposed in this paper has great performance in evaluation metrics than the traditional community detection algorithm, at the same time, the proposed vector construction method can also find potential new herb communities and help innovation of constructing prescription.
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