埃塞俄比亚西北部菲利格-希沃特教学和专科医院艾滋病毒阳性成人坚持抗逆转录病毒治疗的长期预测因素:一项过渡性研究

Awoke Seyoum Tegegne, Principal Ndlovu, T. Zewotir
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引用次数: 0

摘要

在临床试验和实践中,未能坚持药物治疗是慢性病患者面临的共同挑战。许多因素与这次失败有关。先前关于高活性抗逆转录病毒治疗(HAART)依从性预测因子的研究报告并不一致。本研究的主要目的是确定长期坚持HAART治疗的预测因素,并考虑滞后变量作为额外的预测因素。采用过渡模型来确定长期坚持HAART治疗的预测因素。一项回顾性过渡性研究设计在埃塞俄比亚Bahir Dar的Felege-Hiwot教学和专科医院随机选择792名成年患者进行。结果显示,前两个滞后变量()与当前坚持HAART的表现显著相关。如果患者从lag2的粘附水平过渡到lag1的非粘附水平,CD4细胞计数变化的增加与当前的依从性显著相关()。综上所述,从lag2黏附水平转移到lag1非黏附水平的患者,其CD4细胞计数变化与当前黏附水平呈正相关。因此,应适当注意处理每一组病人的具体需要。在这个长期治疗方案中,不坚持HAART是有风险的,应该接受干预措施。在随访中对非依从性患者也应给予教育治疗,以加强长期治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Long term predictors of adherence to Antiretroviral Therapy for HIV positive adults at Felege-Hiwot Teaching and Specialized Hospital, North-West Ethiopia: a transitional study
In clinical trials and practices, failure of adherence to medications is a common challenge among patients with chronic diseases. Many factors are associated with this failure. Reports of previous studies about predictors of adherence to Highly Active Antiretroviral Therapy (HAART) were not consistent. The main objective of this study was to identify predictors of long-term adherence to HAART, considering lag variables as additional predictors. Transitional modeling was used to determine the predictors of long-term adherence to HAART. A retrospective transitional study design was conducted on 792 randomly selected adult patients at Felege-Hiwot Teaching and Specialized Hospital, Bahir Dar, Ethiopia. Results revealed that the first two lag-variables ( ) were significantly associated with performance of current adherence to HAART. The increase in CD4 cell count change was significantly associated with current adherence, if patients made transition from adherent level at lag2 to non-adherent level at lag1 ( ). As a conclusion, for patients who were transferred from adherent level at lag2 to non-adherent level at lag1, their CD4 cell count changes were positively correlated with current adherence level. Due attention should thus be given to address the specific needs of each group of patients. Non-adherence to HAART in this long-term treatment program was at risk and should receive interventional action. Educational therapy during follow-ups should also be given to non-adherent patients to strengthen the era of long-term treatment.
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