治疗性低温对成年雄性Wistar大鼠失血性休克时血浆甲状腺激素水平的影响

F. Faraji Shahrivar, S. Khani, A. Mehdipour, H. Farahani
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摘要

背景与目的:失血性休克是最重要的死亡原因之一。在这项研究中,我们研究了在HS期间治疗性低温(32°C)对血压(BP)的益处以及甲状腺激素在HS期间的作用。材料与方法:24只雄性Wistar大鼠分为常温出血(NH)组和低温出血(HH)组(休克时32℃);然后对这些动物进行麻醉,将一根微导管插入股动脉,一根插入股静脉。动脉标本离心,血浆分离后测定甲状腺激素。将微导管固定在生理记录仪上记录血压。动物通过从股静脉抽血暴露于HS 90分钟,并在HS期间评估血压。结果:HH大鼠在HS的大部分时间和40 min时血压(56.8±4.2 mmHg)明显高于NH大鼠(45.4±3.8 mmHg) (P<0.05)。此外,HH组动物在90分钟休克结束时的血压(63.8±5.5 mmHg)显著高于NH组(39±3.2 mmHg) (P<0.001)。休克结束时,HH组的甲状腺激素T4和T3水平低于NH组(P<0.001)。结论:治疗性低温间接降低甲状腺激素水平,直接降低非重要组织代谢,保留中央动脉血液,升高血压。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Effect of Therapeutic Hypothermia on Plasma Levels of Thyroid Hormones During Hemorrhagic Shock in Adult Male Wistar Rats
Background and Aim: Hemorrhagic shock (HS) is one of the most important causes of death. In this study, we investigated the benefits of therapeutic hypothermia (32°C) during HS on blood pressure (BP) and the role of thyroid hormones during HS. Materials and Methods: Twenty-four male Wistar rats were divided into two normothermic hemorrhagic (NH) and hypothermic hemorrhagic (HH) groups (32°C during shock); the animals were then anesthetized, a microcatheter was inserted into the femoral artery, and one into the femoral vein. The arterial samples were centrifuged, and plasma was isolated to measure thyroid hormones later. The microcatheter was fixed to a physiograph to record BP. Animals were exposed to HS for 90 minutes by withdrawing blood from the femoral vein and BP was assessed during HS. Results: The BP of HH animals was significantly higher in most times of HS and at 40 minutes (56.8±4.2 mmHg) in comparison to NH rats (45.4±3.8 mmHg) (P<0.05). In addition, the amount of BP in HH animals at the end of the shock period at 90 minutes (63.8±5.5 mmHg) was significantly (P<0.001) higher in comparison with the NH groups (39±3.2 mmHg). Levels of thyroid hormones T4 and T3 at the end of shock were lower in the HH group compared to the NH group (P<0.001). Conclusion: Therapeutic hypothermia indirectly reduces the level of thyroid hormones and directly reduces the metabolism of non-vital tissues, preserves blood in the central arteries, and increases BP.
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