Evaluation of α-klotho, FGF-23 and Insulin Resistance in Obese Prediabetics

Aim: Prediabetes is a condition with hyperglycemia and risk of development type 2 diabetes mellitus (T2DM). The aim of this study is to determine the concentrations of blood pressure, serum lipoproteins, glucose and insulin levels as well as the concentrations of α-klotho and FGF-23 parameters. We also aim at the correlation between all these parameters in obese prediabetics and obese normoglycemics. Material and Methods: A total of 26 obese normoglycemic (control group) and 25 obese prediabetic individuals were included in this study. Glucose, haemoglobin A1c (HbA1c) and cholesterols levels were analyzed as part of a routine procedure in the biochemistry laboratories of our hospital using an autoanalyzer. In order to determine α-klotho and fibroblast growth factor-23 (FGF-23) levels, ELISA method was used. Student-t Test and Mann-Whitney U Test were used for evaluation of parameters’ statistical analyzes. Spearman correlation test was used for correlation analysis. Results: According to the findings, a significant increase was detected in serum LDL-C, TC, HbA1c, glucose, insulin and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) levels in the obese prediabetic group compared to the control group (p <0.05). However, serum α-klotho and FGF-23 levels were found to be significantly lower in the obese prediabetic group compared to the control group (p <0.05). α-klotho and FGF-23 values showed strong negative correlation when compared with HOMA-IR values separately (p <0.01). Conclusion: These findings indicate that α-klotho and FGF-23 levels decrease in prediabetic patients and are associated with insulin resistance. The results of our study will make a significant contribution to the literature.