利用模拟和快速傅立叶变换进行代谢系统辨识

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society Pub Date : 1988-11-01 DOI:10.1109/IEMBS.1988.94630

T. Daloze, G. Fink, H. Brunengraber, M.J. Corinthios

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引用次数: 4

摘要

大鼠心脏中酮体代谢的生物学模型强调了乙酰乙酸可逆激活引起的假酮生成。对基于同位素通量微分方程的数学系统进行了数值求解。由于浓度模式不同，无法区分不同组的未知动力学常数，但这些模式可以进一步分析。通过快速z变换算法定位系统极点。Z平面沿恒定阻尼轮廓扫描，使用高效快速傅里叶变换算法。这种模拟和z域扫描方法减少了对实验数据主观分析的需要。

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Metabolic system identification using simulation and fast Fourier transformation

A biological model of ketone body metabolism in the rat heart highlights pseudoketogenesis caused by reversible activation of acetoacetate. A mathematical system based on differential equations of isotopic fluxes is solved numerically. Different sets of unknown kinetic constants cannot be discriminated because of concentration patterns, but these patterns can be further analyzed. System poles are located by a fast Z-transform algorithm. The Z plane is scanned along constant damping contours, using an efficient fast Fourier transform algorithm. This simulation and Z-domain scanning approach reduce the need for subjective analysis of experimental data.<>

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Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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