基于局部表面等离子体共振(LSPR)的血糖监测传感器的数值研究

Kawintida Santavanond, C. Viphavakit, W. Patchoo, H. El-khozondar, W. Mohammed
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引用次数: 1

摘要

本研究旨在应用局部表面等离子体共振(LSPR)、麦克斯韦加内特公式和法布里-珀罗理论,共同设计和开发一种LSPR增强金胶体纳米粒子(AuNPs)传感器,用于生物医学应用,如检测糖尿病患者早期筛查尿液中的葡萄糖水平。在这项工作中,设计并研究了基于LSPR的传感器,通过有效指数的变化导致吸收峰的红移来检测葡萄糖水平。通过与作为稳定剂的柠檬酸三钠(TSC)的不同摩尔比,设计出20 ~ 100 nm范围内的不同尺寸的金纳米颗粒。当纳米金颗粒直径为70 nm,体积分数为0.2的AuNP与葡萄糖溶液时,传感器的最大灵敏度可以达到。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Numerical Investigation of Localized Surface Plasmon Resonance (LSPR) based Sensor for Glucose Level Monitoring
This study aims to apply Localized Surface Plasmon Resonance (LSPR), Maxwell Garnett's formula, and Fabry-Perot theory together to design and develop a LSPR enhanced gold colloidal nanoparticles (AuNPs) sensor to be used in biomedical applications such as detection of glucose level in urine for early stage screening of diabetic patients. In this work, the LSPR based sensor has been designed and studied numerically to detect the glucose level from the change in the effective index resulting in a red shift of the absorption peak. The sensors were designed to have various sizes of the gold nanoparticles in a range between 20 nm and 100 nm by having different molar ratio with Trisodium Citrate (TSC) which acts as stabilizer in the synthesis. The maximum possible sensitivity of the sensor can be achieved with 70 nm diameter of gold nanoparticles at 0.2 volume fraction of AuNP to glucose solution.
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