{"title":"神经性厌食症所致严重转氨炎及铁沉积","authors":"Wilson Lee, Raymond E. Kim","doi":"10.33425/2639-9334.1048","DOIUrl":null,"url":null,"abstract":"Introduction: Anorexia nervosa is associated with a vast amount of general medical complications caused by severe weight loss and malnutrition. Common complications from affected organ systems lead to many physiologic disturbances and multi-organ complications, but rarely severe transaminitis or iron deposition. We discuss a case report of severe transaminitis and iron deposition in a patient with anorexia nervosa. Case: 31 year old male presents to the ED with a history of altered mental status and found to have severe transaminitis. Introduction of nutrition lead to a quick downtrend in liver transaminases with eventual normalization. Additionally, iron deposition as seen in the liver of our patient. Discussion: Severely elevated transaminitis has been a rare complication of anorexia nervosa. Starvation induced autophagy has been a proposed mechanism. There has been one case report of hepatic iron deposition in a patient with anorexia nervosa. Iron deposition has been seen in starved mice livers with gluconeogenesis and alteration in iron homeostasis possibly playing a role.","PeriodicalId":211573,"journal":{"name":"Gastroenterology, Hepatology & Digestive Disorders","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Severe Transaminitis and Iron Deposition Induced by Anorexia Nervosa\",\"authors\":\"Wilson Lee, Raymond E. Kim\",\"doi\":\"10.33425/2639-9334.1048\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: Anorexia nervosa is associated with a vast amount of general medical complications caused by severe weight loss and malnutrition. Common complications from affected organ systems lead to many physiologic disturbances and multi-organ complications, but rarely severe transaminitis or iron deposition. We discuss a case report of severe transaminitis and iron deposition in a patient with anorexia nervosa. Case: 31 year old male presents to the ED with a history of altered mental status and found to have severe transaminitis. Introduction of nutrition lead to a quick downtrend in liver transaminases with eventual normalization. Additionally, iron deposition as seen in the liver of our patient. Discussion: Severely elevated transaminitis has been a rare complication of anorexia nervosa. Starvation induced autophagy has been a proposed mechanism. There has been one case report of hepatic iron deposition in a patient with anorexia nervosa. Iron deposition has been seen in starved mice livers with gluconeogenesis and alteration in iron homeostasis possibly playing a role.\",\"PeriodicalId\":211573,\"journal\":{\"name\":\"Gastroenterology, Hepatology & Digestive Disorders\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-12-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gastroenterology, Hepatology & Digestive Disorders\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.33425/2639-9334.1048\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gastroenterology, Hepatology & Digestive Disorders","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33425/2639-9334.1048","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Severe Transaminitis and Iron Deposition Induced by Anorexia Nervosa
Introduction: Anorexia nervosa is associated with a vast amount of general medical complications caused by severe weight loss and malnutrition. Common complications from affected organ systems lead to many physiologic disturbances and multi-organ complications, but rarely severe transaminitis or iron deposition. We discuss a case report of severe transaminitis and iron deposition in a patient with anorexia nervosa. Case: 31 year old male presents to the ED with a history of altered mental status and found to have severe transaminitis. Introduction of nutrition lead to a quick downtrend in liver transaminases with eventual normalization. Additionally, iron deposition as seen in the liver of our patient. Discussion: Severely elevated transaminitis has been a rare complication of anorexia nervosa. Starvation induced autophagy has been a proposed mechanism. There has been one case report of hepatic iron deposition in a patient with anorexia nervosa. Iron deposition has been seen in starved mice livers with gluconeogenesis and alteration in iron homeostasis possibly playing a role.