基于长期和短期记忆神经网络的阿尔茨海默病早期筛查和预测

Junhao Liang, Fengsen Dong, Hui Qi, Ying Chen, Guohua Qin, Weiwei Li
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摘要

随着我国人口老龄化比例的增加,近年来发病率有所上升。由于该病具有潜伏性发病,病程缓慢且不可逆,因此对阿尔茨海默病的早期筛查和诊断尤为重要。随着计算机计算能力的发展,深度学习领域的探索也逐渐展开。由于长短期记忆神经网络具有记忆单元,可以捕捉时间序列数据的长期依赖性,记录历史信息,在疾病预测方面具有明显优势。LSTM神经网络在记忆、处理滞后数据、防止梯度消失、学习能力等方面具有明显的优势,非常适合预测时间序列数据和阿尔茨海默病等复杂问题。这可以为相关研究提供理论和技术支持,并有助于提高预测的准确性和被广泛接受。本文利用核磁共振图像信息数据,通过长短期记忆神经网络模型预测无阿尔茨海默病(NC)或轻度严重障碍(MCI)患者的人群,获得未来3-5年的发病概率,这也是长短期记忆神经网络在医学预测中的一次有效尝试。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Early Screening and Prediction of Alzheimer's Disease Based on Long-Term and Short-Term Memory Neural Networks
With the increase of the proportion of aging Chinese population, the incidence rate has increased in recent years. Because the disease has a latent onset, the course of the disease is slow and irreversible, and early screening and diagnosis of Alzheimer's disease is particularly important. With the development of computer computing power, the exploration of the field of deep learning has gradually unfolded. Because the long short-term memory neural network has a memory unit, it can capture the long-term dependence of time series data and record historical information, which has obvious advantages in disease prediction. LSTM neural networks have obvious advantages in memory, processing lagging data, preventing gradient disappearance, and learning ability, which makes them very suitable for predicting time series data and complex problems such as Alzheimer's disease. This can provide theoretical and technical support for related research, and help improve the accuracy and wide acceptance of predictions. In this paper, the NMR image information data is used to predict the population of patients without Alzheimer's disease (NC) or mild serious disorder (MCI) through the long-short-term memory neural network model, and the probability of disease in the next 3–5 years is obtained, which is also an effective attempt of long-short-term memory neural network in medical prediction.
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