用于光动力治疗的无线光传输

2018 IEEE International Conference on Service Operations and Logistics, and Informatics (SOLI) Pub Date : 2018-07-01 DOI:10.1109/SOLI.2018.8476796

J. S. Ho

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引用次数: 0

摘要

光通过组织的低穿透性目前限制了光动力疗法(PDT)的治疗深度小于一厘米，即使在近红外波长。我们报告了一种无线光子PDT方法，其中小型化的植入式设备通过无线供电通过厚组织提供受控剂量的光。我们通过在动物模型中激活体内深处的光敏药物和抑制体内肿瘤活性，证明了这种方法的靶向癌症治疗。通过这种方法实现的光传输的多功能性将PDT的空间和时间精度扩展到身体深处的区域。

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Wireless Light Delivery for Photodynamic Therapy

The low penetration of light through tissue currently limits the therapeutic depth of photodynamic therapy (PDT) to less than a centimeter, even at near-infrared wavelengths. We report a wireless photonic approach to PDT in which miniaturized implantable devices deliver controlled doses of light by wireless powering through thick tissue. We demonstrate targeted cancer therapy with this approach by activating light-sensitive drugs deep in the body and suppressing tumor activity in vivo in animal models. The versatility in light delivery enabled by this approach extends the spatial and temporal precision of PDT to regions deep within the body.

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2018 IEEE International Conference on Service Operations and Logistics, and Informatics (SOLI)

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