COVID-19感染后儿童的多发性血栓

Nonkulovski D., Zhivkovska L., Duma F., Sofijanova A. Nonkulovski D., Zhivkovska L., Duma F., Sofijanova, Kirovski I , Muaremoska-Kanzoska L., Alili-Ademi L. Kirovski I , Muaremoska-Kanzoska L., Alili-Ademi L
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摘要

SARS - CoV-2感染可对心血管系统造成急性和慢性损害。d-二聚体水平升高表明,血管功能障碍和凝块形成被认为在Covid-19患者的发病率和死亡率中起着重要作用,导致凝块导致肺栓塞和脑内缺血事件1。目的:探讨SARS - CoV-2感染与血栓性脑损伤等血管并发症的相关性。资料:详细的患者病史,体格检查,特别是注意神经状态和运动技能,以及止血和d-二聚体的血液分析,SARS CoV-2 IgG抗体的血清学和PCR拭子都是该患者诊断过程的一部分。方法:计算机断层扫描和脑磁共振血管造影是诊断过程中的主要影像学工具。结果:1例SARS - CoV-2感染后康复的患者,经脑MRI血管造影证实左大脑中动脉血栓形成,特异性病毒IgG抗体水平高,d -二聚体水平升高,表现为症状性右侧偏瘫。结论:部分SARS冠状病毒感染者可发生缺血性脑卒中。患者血清中抗SARS - CoV-2的IgG抗体水平升高证实了这一联系。这种血管病毒后并发症可引起不同类型的残疾,表现为神经功能障碍和凝血功能障碍。早期抗凝治疗和物理治疗可改善预后。关键词:血栓形成,SARS -2,脑,偏瘫
本文章由计算机程序翻译,如有差异,请以英文原文为准。
MULTIPLE TROMBOSIS IN CHILD WITH POST COVID-19 INFECTION
Introduction: SARS CoV-2 infection can cause acute, as well as chronic damage to the cardiovascular system. Blood vessel dysfunction and clot formation, as suggested by elevated D-dimer levels, are thought to play a significant role in morbidity, as well as in mortality in Covid-19 patients, leading to clots causing pulmonary embolisms and ischemic events within the brain1. Aim: To confirm the correlation between SARS CoV-2 infection and possibility for vascular complication, including thrombotic brain lesion. Materials: Detailed patient’s history, physical examination particularly noting the neurological status and locomotor skills, as well as blood analysis with hemostasis and d-dimers, serology for SARS CoV-2 IgG antibodies and PCR swab were all part of the diagnostic process for this patient. Methods: Computed tomography and brain MRI with angiography were main imaging tools used in the diagnostic process. Results: Thrombosis of the left middle cerebral artery was confirmed on brain MRI with angiography in a patient recovered from SARS CoV-2 infection, noted with high levels of IgG antibodies to the particular virus and elevated D-dimer levels, presenting with symptomatic right sided hemiparesis. Conclusion: Some of the patients recovered from SARS CoV 2 infection can develop ischemic stroke. This link is confirmed by elevated levels of IgG antibodies in patient’s serum against SARS CoV-2. This kind of vascular post viral complication can cause different kind of disability, presented with neurological impairment and coagulation disorders. The prognose is improving with anticoagulant and physical therapy started early.2 Keywords: Thrombosis, SARS Cov-2, Brain, Hemiparesis
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