微线圈形状及软磁材料芯对局灶性微磁神经刺激效果的影响

Renata Saha, Kai Wu, Jian‐Ping Wang
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引用次数: 0

摘要

微磁神经刺激$(\upmu \text{MS})$虽然还处于起步阶段,但在神经元的空间选择性激活方面已经显示出令人鼓舞的结果。该装置是微米大小的线圈或微线圈(\upmu \mathbf{线圈}),其工作原理是法拉第电磁感应定律。当一个时变电流通过这些线圈时,它们会产生一个时变磁场,这个磁场反过来会产生一个激活神经元的电场。这些线圈不受生物污染的影响,因为这种感应电场与组织没有直接的电化学接触。然而,这些$\upmu \mathbf{线圈}$具有很高的操作功率,这会导致对神经元产生不良的热效应。在这项工作中,我们研究了软磁材料(SMM)磁芯在这些$\upmu \text{线圈}$上的功效,以解决$\upmu \text{MS}$存在的两个挑战。首先,尽量减少这些$\upmu \text{线圈}$的功耗。第二,实现更精确和更集中的神经组织激活。我们从磁场和感应电场的空间等高线图上研究了3种尺寸相当的$\upmu \text{线圈}$。此外,我们还研究了锥形和棒状两种形状的SMM磁芯在获得空间聚焦磁场和增加感应电场强度方面的效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of microcoil shape and the efficacy of soft magnetic material cores in focal micromagnetic neurostimulation
Micromagnetic neurostimulation $(\upmu \text{MS})$, despite being in its infancy, has shown promising results in spatially selective activation of neurons. The devices are micrometer-sized coils or microcoils $(\upmu \mathbf{coils})$ which work on the principle of Faraday's Law of electromagnetic induction. Upon applying a time-varying current through these $\upmu \text{coils}$ they generate a time-varying magnetic field which in turn induces an electric field that activates the neurons. These $\upmu \text{coils}$ are spared from biofouling nuances as this induced electric field is not in direct electrochemical contact with the tissues. However, these $\upmu \mathbf{coils}$ have a high power of operation which lead to undesirable thermal effects on neurons. In this work, we have studied the efficacy of soft magnetic material (SMM) cores on these $\upmu \text{coils}$ to solve two existing challenges for $\upmu \text{MS}$. First, to minimize the power consumption for these $\upmu \text{coils}$. Second, to achieve even more precise and focal activation of the neural tissues. We have studied 3 shapes of $\upmu \text{coils}$ with comparable sizes in terms of spatial contour plots of magnetic field and induced electric field. Furthermore, the efficacy of 2 shapes of SMM cores, cone and rod, of varying sizes have been studied to obtain a spatially focal magnetic field and increased magnitude of induced electric field.
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