5-Aminolevulinic acid photodynamic therapy: an effective treatment modality for female precancerous lesions: experience of a single center

A total of 62 female patients who underwent ALA-PDT at the Gynecology Department of Henan Province People's Hospital in 2018 were retrospectively assessed. Lesions included 24 case of LSIL, 13 case of HSIL, 12 case of VAIN, 2 case of VIN and 11 case of VL. Three-six sessions of ALA-PDT were carried out at intervals of ten days. The treatment efficacy was evaluated by colposcopy, TCT and HPV dectection. After one month follow-up, The effective rate of LSI, HSIL, VAIN, VIN and VL were 70.8%, 84.6%, 83.3%, 100% and 100%. After three month follow-up, The effective rate of LSIL, HSIL, VAIN, VIN and VL were 83.3%, 92.3%, 83.3%, 100% and 100%. After six month follow-up, The effective rate of LSIL, HSIL, VAIN, VIN and VL were 87.5%, 92.3%, 91.7%, 100% and 100%. Our experience show that ALA-PDT is an effective treatment modality for female genital precancerous lesions. Keywords: 5-aminolevulinic acid photodynamic therapy, Low-grade cervical squamous intraepithelial lesions,