Effects of bilateral microinjections of ibotenic acid into neostriatal region and forced exercise on spatial learning and memory and anthropometric characteristics of male rats

the in of and forced treadmill exercise on anthropometric characteristics and learning and spatial of Materials and Methods : 48 male Wistar rats were randomly divided into six groups: Control, Sham-lesioned, Lesioned, Exercise, Exercise + Sham-lesioned and Exercise + lesioned. Lesion was made by bilateral microinjection of ibotenic acid into neostriatum. The exercise groups were subjected to a protocol of running on a treadmill for four weeks Results: Findings showed that ibotonic acid microinjection significantly decreased learning and spatial memory ( P <0.05). Forced treadmill exercise could get better learning and spatial memory, but it could not significantly improve learning and spatial memory impairment induced by ibotenic acid injection in striatum. On the other hand, four weeks forced treadmill exercise enhanced anthropometric characteristics in lesion group ( P = 0.03). Conclusion: The present results suggest that striatum had a main role on learning and spatial memory, while four forced treadmill exercise could not improve spatial learning and memory impairment induced by ibotenic acid injection in striatum.