EVALUATION OF THE EFFECTIVENESS OF THE USE OF A SYNBIOTIC COMPLEX CONTAINING STREPTOCOCCUS THERMOPHILUS LYSATE AMONG ADOLESCENTS WITH A HIGH RISK OF CARIES

Relevance. Assessment of the risk of occurrence, prevention and treatment of caries and gingivitis in adolescents. Objective. To evaluate the effectiveness of the use of an oral rinse containing Streptococcus thermophilus lysate in adolescents with a high risk of caries. Materials and methods. The examined 25 adolescents aged 11 to 18 years used a mouthwash "Dentabalance ®" synbiotic complex for a month. The effectiveness of preventive and therapeutic measures was evaluated before and after a month of using the rinse aid by the oral hygiene index OHI-S, periodontal index PMA and indicators of mixed saliva by determining the activity of enzymes by spectrophotometric method: aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), alkaline phosphatase (alkaline phosphatase) in IU/l; by gas-liquid chromatography, the amount of acetic, propionic and butyric acids in mol/l. Results. High index values were observed in adolescents with a high risk of caries of permanent teeth: CPU (6,7), OHI-S (2,43 ± 0,07), PMA (62,1 ± 3,0%). In the mixed saliva, increased activity of enzymes was detected, the values of which were AST — 42.0 ± 8.1IU/l; LDH — 490 ± 51.2 IU/l; SCHF — 30.6 ± 1.94IU /l, the indicators of acetic and propionic acids were 2.38 ± 0.48 mol/l and 0.25 ± 0.03 mol/l, respectively, and the content of butyric acid was not determined. After the use of a mouthwash containing Streptococcus thermophilus lysate by adolescents, the indicators of the hygiene index OHI-S decreased statistically significantly (p < 0.05) by 54.1% and the values of the PMA index by 53.3%; in mixed saliva, a decrease in the activity of AST was determined by 3.5 times, LDH by 4.7 times, alkaline phosphatase by 1.4 times, and also, the number of short-chain organic acids — acetic by 4.7 times and propionic by 1.4 times. Conclusions. The Dentabalance ® mouthwash is a synbiotic complex containing Streptococcus thermophilus lysate, has an anti-carious and anti-inflammatory effect, which allows it to be recommended for use by adolescents with a high risk of caries and gingivitis.Relevance: Due to the high prevalence of caries and inflammatory lesions of periodontal tissues in adolescents, the assessment of the risk of occurrence, prevention and treatment of these diseases remains relevant.