K. Szántó, Z. Mezei, D. Kata, I. Földesi, T. Nyári, A. Fábián, M. Rutka, R. Bor, A. Bálint, Á. Milassin, Z. Szepes, F. Nagy, K. Palatka, K. Farkas, T. Molnár
{"title":"抗tnf和硫嘌呤联合治疗确实会影响炎症性肠病患者的药物代谢物水平，但与机体成分无关:一项横断面研究","authors":"K. Szántó, Z. Mezei, D. Kata, I. Földesi, T. Nyári, A. Fábián, M. Rutka, R. Bor, A. Bálint, Á. Milassin, Z. Szepes, F. Nagy, K. Palatka, K. Farkas, T. Molnár","doi":"10.33570/ceujgh.7.4.164","DOIUrl":null,"url":null,"abstract":"In this cross-sectional, real-life study we have investigated the potential association between 6-thioguanine nucleotide (6-TGN) and anti-TNF [infliximab (IFX), adalimumab (ADA)], anti-drug antibody levels and body composition parameters. Based on our results thiopurine and anti-TNF combination therapy resulted in decreased antibody formation in IFX-treated patients. AZA-ADA-treated patients showed increased anti-TNF drug concentrations, regardless of antibody formation. Drug metabolites did not correlate with body composition parameters.","PeriodicalId":103444,"journal":{"name":"Central European Journal of Gastroenterology and Hepatology","volume":"25 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Combination therapy with anti-TNFs and thiopurines does affect drug metabolite levels but it is not associated with body composition in inflammatory bowel disease patients: A cross-sectional study\",\"authors\":\"K. Szántó, Z. Mezei, D. Kata, I. Földesi, T. Nyári, A. Fábián, M. Rutka, R. Bor, A. Bálint, Á. Milassin, Z. Szepes, F. Nagy, K. Palatka, K. Farkas, T. Molnár\",\"doi\":\"10.33570/ceujgh.7.4.164\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this cross-sectional, real-life study we have investigated the potential association between 6-thioguanine nucleotide (6-TGN) and anti-TNF [infliximab (IFX), adalimumab (ADA)], anti-drug antibody levels and body composition parameters. Based on our results thiopurine and anti-TNF combination therapy resulted in decreased antibody formation in IFX-treated patients. AZA-ADA-treated patients showed increased anti-TNF drug concentrations, regardless of antibody formation. Drug metabolites did not correlate with body composition parameters.\",\"PeriodicalId\":103444,\"journal\":{\"name\":\"Central European Journal of Gastroenterology and Hepatology\",\"volume\":\"25 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1900-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Central European Journal of Gastroenterology and Hepatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.33570/ceujgh.7.4.164\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Central European Journal of Gastroenterology and Hepatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33570/ceujgh.7.4.164","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Combination therapy with anti-TNFs and thiopurines does affect drug metabolite levels but it is not associated with body composition in inflammatory bowel disease patients: A cross-sectional study
In this cross-sectional, real-life study we have investigated the potential association between 6-thioguanine nucleotide (6-TGN) and anti-TNF [infliximab (IFX), adalimumab (ADA)], anti-drug antibody levels and body composition parameters. Based on our results thiopurine and anti-TNF combination therapy resulted in decreased antibody formation in IFX-treated patients. AZA-ADA-treated patients showed increased anti-TNF drug concentrations, regardless of antibody formation. Drug metabolites did not correlate with body composition parameters.
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