{"title":"血浆纤溶酶-α2纤溶酶抑制剂复合物对糖尿病肾病患者纤溶的影响","authors":"Mitsunori Yagame, Kazuhiko Eguchi, Daisuke Suzuki, Hideo Machimura, Hiroshi Takeda, Wataru Inoue, Kurumi Tanaka, Hideaki Kaneshige, Yasuo Nomoto, Hideto Sakai","doi":"10.1016/0891-6632(90)90018-Z","DOIUrl":null,"url":null,"abstract":"<div><p>Activation of fibrinolysis in patients with diabetic nephropathy was determined by the plasma levels of plasmin-<em>α</em><sub>2</sub> plasmin inhibitor complexes (<em>α</em><sub>2</sub>PIC) using a one-step sandwich enzyme immunoassay (EIA). Plasma levels of <em>α</em><sub>2</sub>PIC in diabetic patients with persistent proteinuria were significantly higher than those in diabetic patients without proteinuria, patients with chronic glomerulonephritis, and healthy adults. Plasma levels of <em>α</em><sub>2</sub>PIC in diabetic patients with intermittent proteinuria were also significantly higher than those of diabetic patients without proteinuria, patients with chronic glomerulonephritis, and healthy adults. Diabetic patients have been suggested to have a hypercoagulable state. The findings obtained from this study indicated that activation of fibrinolysis might counteract the hypercoagulable state in patients with diabetic nephropathy.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"4 4","pages":"Pages 175-178"},"PeriodicalIF":0.0000,"publicationDate":"1990-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(90)90018-Z","citationCount":"13","resultStr":"{\"title\":\"Fibrinolysis in patients with diabetic nephropathy determined by plasmin-α2 plasmin inhibitor complexes in plasma\",\"authors\":\"Mitsunori Yagame, Kazuhiko Eguchi, Daisuke Suzuki, Hideo Machimura, Hiroshi Takeda, Wataru Inoue, Kurumi Tanaka, Hideaki Kaneshige, Yasuo Nomoto, Hideto Sakai\",\"doi\":\"10.1016/0891-6632(90)90018-Z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Activation of fibrinolysis in patients with diabetic nephropathy was determined by the plasma levels of plasmin-<em>α</em><sub>2</sub> plasmin inhibitor complexes (<em>α</em><sub>2</sub>PIC) using a one-step sandwich enzyme immunoassay (EIA). Plasma levels of <em>α</em><sub>2</sub>PIC in diabetic patients with persistent proteinuria were significantly higher than those in diabetic patients without proteinuria, patients with chronic glomerulonephritis, and healthy adults. Plasma levels of <em>α</em><sub>2</sub>PIC in diabetic patients with intermittent proteinuria were also significantly higher than those of diabetic patients without proteinuria, patients with chronic glomerulonephritis, and healthy adults. Diabetic patients have been suggested to have a hypercoagulable state. The findings obtained from this study indicated that activation of fibrinolysis might counteract the hypercoagulable state in patients with diabetic nephropathy.</p></div>\",\"PeriodicalId\":77636,\"journal\":{\"name\":\"The Journal of diabetic complications\",\"volume\":\"4 4\",\"pages\":\"Pages 175-178\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1990-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0891-6632(90)90018-Z\",\"citationCount\":\"13\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of diabetic complications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/089166329090018Z\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of diabetic complications","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/089166329090018Z","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Fibrinolysis in patients with diabetic nephropathy determined by plasmin-α2 plasmin inhibitor complexes in plasma
Activation of fibrinolysis in patients with diabetic nephropathy was determined by the plasma levels of plasmin-α2 plasmin inhibitor complexes (α2PIC) using a one-step sandwich enzyme immunoassay (EIA). Plasma levels of α2PIC in diabetic patients with persistent proteinuria were significantly higher than those in diabetic patients without proteinuria, patients with chronic glomerulonephritis, and healthy adults. Plasma levels of α2PIC in diabetic patients with intermittent proteinuria were also significantly higher than those of diabetic patients without proteinuria, patients with chronic glomerulonephritis, and healthy adults. Diabetic patients have been suggested to have a hypercoagulable state. The findings obtained from this study indicated that activation of fibrinolysis might counteract the hypercoagulable state in patients with diabetic nephropathy.
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