氢氯噻嗪在现实世界中的安全性:对意大利药品管理局(AIFA)公告的评论

Magro Valerio Massimo, Coppola Carla, Boccalone Eugenio, Caturano Michele, Scala Giovanni, Verrusio Walter
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引用次数: 0

摘要

•第1页3•Magro等人。引用本文:Magro VM, Coppola C, Boccalone E, Caturano M, Scala G,等。(2019)氢氯噻嗪在现实世界中的安全性:对意大利药品管理局(AIFA)公告的评论。国际临床心脏病杂志6:160。doi.org/10.23937/2378-2951/1410160录用时间:2019年10月12日;出版日期:2019年10月14日版权所有:©2019 Magro VM, et al。这是一篇根据知识共享署名许可协议发布的开放获取文章,该协议允许在任何媒体上不受限制地使用、分发和复制,前提是要注明原作者和来源。容积、低钠血症、高钙血症、高血糖症、血脂异常)[9]。关于电解质失衡,噻嗪类药物引起的低钠血症无疑是一种重要的医学病症,它经常出现在内科,在患者亚组中,服用氢氯噻嗪类药物的体弱患者(通常是老年人)发病率很高[10,11]。氢氯噻嗪干扰葡萄糖稳态的机制也尚未得到很好的理解[12-14]。也有一系列的副作用,幸运的是很少,但在医学文献中有描述,从狼疮的出现[15],间质性肺疾病[16],甚至严重的过敏状态[17],肺水肿[18-20],所有这些情况都与分子本身引起的免疫变化有关。对感觉器官(听觉减退)的影响更为人所知,但不太罕见(尽管调查频率较低,特别是在老年受试者中),有来自警惕药物器官的各种报告,对这种不良事件的诊断有明确的适应症(Austin Bradford-Hill标准,Naranjo标准),很好地应用于药物警戒[21,22]。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Safety of Hydrochlorothiazide in the Real World: A Commentary on the Italian Medicines Agency (AIFA) Pronouncements
• Page 1 of 3 • Magro et al. Int J Clin Cardiol 2019, 6:160 Citation: Magro VM, Coppola C, Boccalone E, Caturano M, Scala G, et al. (2019) Safety of Hydrochlorothiazide in the Real World: A Commentary on the Italian Medicines Agency (AIFA) Pronouncements. Int J Clin Cardiol 6:160. doi.org/10.23937/2378-2951/1410160 Accepted: October 12, 2019; Published: October 14, 2019 Copyright: © 2019 Magro VM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. volume, hyponatremia, hypercalcemia, hyperglycemia, dyslipidemia) [9]. Regarding the electrolyte imbalances, thiazide-induced hyponatremia is certainly an important medical condition, that is regularly present in the internal medicine departments and it causes substantial morbidity to frail patients, often elderly, who are taking hydrochlorothiazide, in subgroups of patients [10,11]. Equally not yet well understood is the mechanism by which hydrochlorothiazide interferes with the glucose homeostasis [12-14]. There is also a whole range of side effects, fortunately rarer, but described in the medical literature, ranging from the appearance of lupus [15], interstitial lung disease [16], even severe allergic states [17], pulmonary edema [18-20], all conditions linked to immunological changes induced by the molecule itself. The effect on the sense organs (hypoacusis) is more known and less rare (although investigated with low frequency, especially in the elderly subjects), with various reports from the organs of vigilance drug, for which there are well defined indications for the diagnosis of this adverse event (Austin Bradford-Hill criteria, Naranjo criteria), well applied in pharmacovigilance [21,22].
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