咪唑介导的螺菌吲哚在水中的合成

M. N. Khan, D. Parmar, H. Bhatt
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引用次数: 4

摘要

本文介绍了咪唑作为高效有机催化剂合成复杂小分子螺菌吲哚的方法。以水为绿色溶剂,进行了isatin、丙二腈和烯化4-羟基香豆素的三组分偶联反应。该反应是用两性有机催化剂咪唑进行的,以高收率构建螺旋分子。该方案的显著特点是反应条件中性,催化剂价格低廉,不含金属,不含强酸/强碱,反应介质可重复使用,无需柱层析分离。这种方法对于结构复杂、高度功能化的螺菌吲哚分子具有重要的药物化学应用价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Imidazole mediated synthesis of spirooxindoles in water using isatin as a privileged scaffold
This work describes the synthesis of complex small molecules spirooxindoles using imidazole as an efficient organocatalyst. The three components coupling reactions of isatin, malononitrile and enolizable 4-hydroxycoumarin were performed in water as a green solvent. The reaction is done with imidazole an amphoteric organocatalyst to construct spiro-molecules in high yields. The significant features of this protocol are neutral reaction condition, readily available low cost catalyst, metal free, strong acid/base free, and reusable reaction medium with no column chromatography separation. This methodology is useful for the easy access of structurally complex, highly functionalized spirooxindole molecules with important medicinal chemistry applications.
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CiteScore
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