R. Haselberg, B. Pirok, Andrea F. G. Gargano, Isabelle Kohler
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Clinical Metabolomics: Expanding the Metabolome Coverage Using Advanced Analytical Techniques
This review article discusses the novel separation and detection strategies that are considered promising in clinical metabolomics to enhance the metabolome coverage. It includes hydrophilic interaction chromatography (HILIC), supercritical fluid chromatography (SFC), multidimensional LC approaches, as well as ion-mobility mass spectrometry (IM-MS) and data-independent acquisition (DIA) analysis methods.
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