高氧治疗膝盖骨关节炎慢性疼痛的治疗效果

Medical Scope Journal Pub Date : 2023-08-18 DOI:10.35790/msj.v5i2.46565

Benny G. Siahaan, Rangga B. V. Rawung, M. Hatibie

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引用次数: 0

摘要

摘要:骨关节炎(Osteoarthritis, OA)是一种以进行性软骨退变、软骨下骨改变、骨赘形成、鼻窦炎或关节炎为特征的退行性关节疾病。骨关节炎治疗的目的是减轻疼痛，增加关节功能，减少残疾。高压氧治疗(Hyperbaric oxygen therapy, HBOT)可以抑制星形胶质细胞的激活和炎症因子的产生，维持感觉信息通过背侧神经元的传递和整合，从而减轻疼痛。本研究旨在评价HBOT治疗膝骨关节炎慢性疼痛的疗效。这是一项平行、双臂、安慰剂对照、随机的临床试验，在Manado的两家医院进行，即Badan Layanan Umum Rumah Sakit Umum Pusat教授Dr. R. D. Kandou和Rumah Sakit Siloam。结果获得44例伴有慢性疼痛的1级至2级膝骨关节炎患者作为研究对象，分为HBOT干预组和对照组。采用Shapiro-Wilk检验确定数值变量的正态性。经统计检验证实，HBOT前后患者VAS评分分布与对照组比较，差异无统计学意义(p=0.421, p=0.634)。综上所述，高压氧治疗可以减轻膝关节骨关节炎的慢性疼痛。关键词:膝关节骨关节炎;高压氧治疗;摘要:骨关节炎(OA)是指骨关节炎、骨关节炎、骨关节炎、骨关节炎、骨关节炎、骨关节炎、骨关节炎、骨关节炎等。Tujuan penatalaksanaan OA ialah为她meredakan nyeri, meningkatkan fungsi,丹membatasi disabilitas Terapi oksigen hiperbarik (TOHB) dapat menginhibisi aktivasi astrosit丹produksi faktor inflamatorik舒达mempertahankan transmisi丹integrasi informasi sensori melalui神经元背sehingga nyeri menurun。Penelitian ini bertujuan untuk menilai efektifitas TOHB dalam penalalaksanaan和nyeri kronik pata lutut。Penelitian ini进行了一项平行、双臂、安慰剂对照、随机临床试验，研究结果表明，研究人员在研究中发现了一种新的方法，即在研究中发现了一种新的方法，即在研究中发现一种新的方法，即在研究中发现一种新的方法。[4] [1] [1] [2] [1] [1] [1] [1] [1] [2] [1] [2] [1] [2] [1] [2] [1] [2] [1] [2] [1] [2] [1] [2] [1] [1] [2] [1] [2] [1] [2] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [2]Penentuan normalitas variable numerik dilakukan menggunakan uji Shapiro-Wilk。哈西尔统计量(hsil)与对照组(p=0,421和p=0,634)之间的相关性(p=0,421和p=0,634)。猕猴骨关节炎是一种典型的骨关节炎。骨性关节炎;Terapi oksign hiperbarik;nyeri kronik

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Efektivitas Terapi Oksigen Hiperbarik pada Nyeri Kronik Osteoartritis Lutut

Abstract: Osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage degeneration, subchondral bone changes, osteophyte formation, sinovitis or arthritis. The aim of osteoarthritis management is to reduce pain, increase joint function, and decrease disability. Hyperbaric oxygen therapy (HBOT) can inhibit astrocyte activation and inflammatory factor production, and maintain transmission and intergration of sensoric information through dorsal neurons, therefore, resulting in pain reduction. This study aimed to evaluate the effectiveness of HBOT in chronic pain of knee osteoarthritis. This was a parallel, two-arm, placebo-controlled, randomized clinical trial in adults with knee osteoarthritis at two hospitals in Manado, namely Badan Layanan Umum Rumah Sakit Umum Pusat Prof. Dr. R. D. Kandou and Rumah Sakit Siloam. The results obtained 44 patients suffered from knee osteoarthritis grade 1 dan 2 associated with chronic pain as subjects, divided into two groups namely intervention with HBOT and control groups. Determination of normality of numeric variables was performed with Shapiro-Wilk test. The statistic test confirmed that the distribution of VAS scores was relatively not different between before and after HBOT, and the control group (p=0.421 and p=0.634). In conclusion, hyperbaric oxygen therapy can be used to reduce chronic pain in knee osteoarthritis. Keywords: knee osteoarthritis; hyperbaric oxygen therapy; chronic pain Abstrak: Osteoartritis (OA) merupakan suatu penyakit sendi degeneratif yang dikarakteristikkan dengan degenerasi kartilago progresif, perubahan tulang subkondral, pembentukan osteofit, dan sinovitis atau inflamasi sendi. Tujuan penatalaksanaan OA ialah untuk meredakan nyeri, meningkatkan fungsi, dan membatasi disabilitas Terapi oksigen hiperbarik (TOHB) dapat menginhibisi aktivasi astrosit dan produksi faktor inflamatorik serta mempertahankan transmisi dan integrasi informasi sensori melalui neuron dorsal sehingga nyeri menurun. Penelitian ini bertujuan untuk menilai efektifitas TOHB dalam penatalaksanaan nyeri kronik pada OA lutut. Penelitian ini didesain sebagai suatu parallel, two-arm, placebo-controlled, randomized clinical trial pada dewasa dengan OA lutut di dua rumah sakit di Manado, Badan Layanan Umum Rumah Sakit Umum Pusat Prof. Dr. R. D. Kandou dan Rumah Sakit Siloam. Sebanyak 44 pasien OA lutut grade 1 dan 2 dengan nyeri kronik menjadi subjek penelitian, yang dibagi secara acak atas dua kelompok: intervensi TOHB dan kontrol. Penentuan normalitas variabel numerik dilakukan menggunakan uji Shapiro-Wilk. Hasil statistik mengonfirmasi distribusi penurunan skor VAS relatif tidak berbeda bermakna sebelum dan setelah TOHB dan kelompok kontrol (p=0,421 dan p=0,634). Simpulan penelitian ini terapi oksigen hiperbarik kemungkinan dapat menurunkan nyeri kronik pada penderita osteoartristis lutut. Kata kunci: osteoartritis lutut; terapi oksigen hiperbarik; nyeri kronik

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Medical Scope Journal

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