The Impact of Topically Applied 1% Phenytoin Gel on Treatment of Periodontitis Stage II and III Grade A

Aim: The aim of the present study was to evaluate the efficacy of topically applied 1% phenytoin as an adjunctive treatment in Stage II or III, Grade A periodontitis patients. Subjects and Methods: This study was designed as a split-mouth randomized controlled clinical, carried out on 20 patients of both sexes (12 female and 8 male), aged from (33-55) years with mean age (43.25± 6.64) with stage II or III, grade A periodontitis. Patients’ sides were classified randomly into the following groups: Group I: included 20 sides with Stage II or III, Grade A periodontitis patients treated by scaling and root planing alone. Group II: included 20 sides with Stage II or III, Grade A periodontitis patients treated by scaling and root planing combined with 1% phenytoin gel. All patients were evaluated clinically at; baseline, 1, 3 and 6 months using plaque index (PI), gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL) and radiographically by evaluation of the marginal bone level (MBL). Results: Phenytoin group: showed reduction in PPD and CAL, as well as significant gain in MBL than group I at 6 months after treatment Conclusion: The adjunctive use of 1% PHT in-situ gel exhibited an attractive effect on probing pocket depth reduction clinical attachment gain in non-surgical treatment of stage II and III grade A periodontitis. Phenytoin 1% in-situ gel seemed to have an osteogenic efficacy through the reported marginal bone gain in treatment of stage II and III grade A periodontitis patients.