托瑞米芬对NZB/NZW小鼠nk细胞活性的影响

Anni Wärri, Lauri Kangas
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引用次数: 9

摘要

研究了托瑞米芬对NZB/NZW小鼠脾脏nk细胞的影响,并与他莫西芬和雌二醇进行了比较。与雌二醇不同,像他莫昔芬一样,托瑞米芬不影响nk细胞的活性。低剂量(0.1和10.0 mg/kg)的托瑞米芬没有抑制,但高剂量的托瑞米芬和他莫西芬(50 mg/kg,持续6周)抑制了人干扰素α对细胞的刺激作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of toremifene on the activity of NK-cells in NZB/NZW mice

The effect of toremifene on NK-cells isolated from the spleen of NZB/NZW mice was studied in comparison to tamoxifen and estradiol. Unlike estradiol but like tamoxifen, toremifene did not influence the activity of NK-cells. Low doses (0.1 and 10.0 mg/kg) of toremifene did not suppress, but a high dose of toremifene and tamoxifen (50 mg/kg for 6 weeks) suppressed the stimulating effect of human interferon alpha on the cells.

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