New noninvasive index of the left ventricular inotropic state.

In order to confirm in clinical material a new contractile index, the systolic circumferential wall stress/end systolic muscle index ratio (SCS/ESMI), there were compared two groups of patients with pressure overload ventricular hypertrophy, with and without global compliance disturbances (Group B1 = 36; Group B2 = 28) and two groups of age and body surface area-matched healthy individuals (Group A1 = 36; Group A2 = 28). The new index of the contractile or muscle function, the SCS/ESMI ratio, was so effective in the research sample as the systolic circumferential wall stress/cavitary volume ratio, the SCS/ESVI. The product of the systolic contractile index, the SCS/ESVI, and ejection fraction (SCI X EF), as an integrated left ventricular parameter, showed that the ejection or pump function reduction was artificial in patients with an increased afterload and normal preload. The confidence limit for the SCI X EF on the level of 95% is 3.5, and for the product of the new systolic muscle index and ejection fraction, the SMI X EF, is 99. The inaugurated functional parameters could serve for revealing "false positive" cardiac failure or they could reveal the true reduction of the muscle contractile cardiac function by the artificially increased and "normal" ejection phase indices.