A system for detecting chemically-induced changes in cerebral blood flow using transcranial Doppler sonography in a dog model

An experiment designed to develop a computer-based system capable of detecting chemically induced changes in cerebral blood flow (CBF) in a dog before the onset of overt clinical or behavioral symptoms is discussed. The system uses transcranial Doppler sonography (TCD) to noninvasively measure changes in CBF after low-level exposure to deltamethrin. Since changes in CBF often occur before other clinical signs, a method of detecting these changes could be used to detect exposures to potentially hazardous chemicals. Initial results indicate that TCD does seem to be sensitive enough to detect changes in blood flow velocity caused by deltamethrin, but improvements in the methodology need to be made and more data need to be collected to try to obtain more consistent results.<>