从妊娠晚期到儿童期，气道平滑肌层的生长最初是由肥大和随后的增生介导的

Respirology (Carlton, Vic.) Pub Date : 2022-03-09 DOI:10.1111/resp.14240

Kimberley C. W. Wang, G. Donovan, S. Saglani, T. Mauad, A. James, J. Elliot, P. Noble

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引用次数: 2

摘要

气道平滑肌(ASM)层在发育过程中增厚。识别ASM正常结构成熟的机制揭示了易受疾病过程影响的途径。本研究描述了从胎儿期到儿童期ASM层的增厚，并从肥大、增生和细胞外基质(ECM)沉积等方面阐明了其潜在机制。

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Growth of the airway smooth muscle layer from late gestation to childhood is mediated initially by hypertrophy and subsequently hyperplasia

The airway smooth muscle (ASM) layer thickens during development. Identifying the mechanism(s) for normal structural maturation of the ASM reveals pathways susceptible to disease processes. This study characterized thickening of the ASM layer from foetal life to childhood and elucidated the underlying mechanism in terms of hypertrophy, hyperplasia and extracellular matrix (ECM) deposition.

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Respirology (Carlton, Vic.)

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