[l-半胱氨酸对乙醇性大鼠肝损伤保护作用的组织病理学评价]。

Roczniki Akademii Medycznej w Bialymstoku = Annales Academiae Medicae Bialostocensis Pub Date : 1990-01-01

K Worowski, L Chyczewski, E Skrzydlewska

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引用次数: 0

摘要

以标准饲料喂养的大鼠，连续4周以0.6 g/100 g体重的剂量乙醇中毒。这种中毒引起肝空泡变性、糖原颗粒消失、肝细胞脂肪变性和肝局灶性坏死改变。摄入0.012和0.024 g/100 g/24 h的半胱氨酸食物可显著防止乙醇中毒大鼠肝脏组织病理改变。大剂量半胱氨酸(0.044 g/100 g/24小时)会加剧乙醇引起的大鼠肝脏组织病理变化。

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[Histopathological evaluation of protective effect of L-cysteine in ethanol-induced liver damage in rats].

Rats fed standard diet were intoxicated during 4 weeks with ethanol at the dose of 0.6 g/100 g of the body weight. This poisoning causes vacuolar degeneration, disappearance of glycogen granules, steatosis of hepatocytes and focal necrosis changes in the liver. The intake of food with cysteine at the dose of 0.012 and 0.024 g/100 g/24 hrs markedly prevents histopathological changes in the liver of rats intoxicated with ethanol. Larger amounts of cysteine (0.044 g/100 g/24 hrs) intensify histopathological changes caused by ethanol in the liver of rats.

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Roczniki Akademii Medycznej w Bialymstoku = Annales Academiae Medicae Bialostocensis

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