胶原降解产物(CDP)对中枢多巴胺能系统的影响。

Acta physiologica Polonica Pub Date : 1990-11-01
E Telejko, J Maćkowiak, K Wiśniewski
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引用次数: 0

摘要

研究了胶原降解产物(分子量约为3000 D的CDP I和分子量约为1200 D的CDP II)对中枢多巴胺能系统的影响。注意到这两部分在阿吗啡刻板印象试验中的作用差异;在使用诱导刻板印象的药物之前,给大鼠5微克的CDP I增强了动物的刻板印象行为,而40微克的剂量则显著抑制了这种行为。另一方面,方案二对这种陈规定型没有影响。剂量分别为15微克和40微克的两部分都增强了安非他明引起的刻板印象。在观察前30分钟给药的CDP I和CDP II(15和40微克)能增强氟哌啶醇的催化作用,而在观察前45分钟给药的CDP I和CDP II组分均能减轻氟哌啶醇的催化作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of collagen degradation products (CDP) on the central dopaminergic system.

The effect of collagen degradation products (CDP I--molecular weight circa 3000 D and CDP II--molecular weight circa 1200 D) on the central dopaminergic system was studied. Differences in the action of both these fractions in the apomorphine stereotypy test were noted; CDP I administered to rats in a dose of 5 micrograms just before application of the drug inducing the stereotypy enhanced the stereotypic behaviour of the animals whereas a dose of 40 micrograms significantly inhibited such behaviour. CDP II, on the other hand, had no effect on this type of stereotypy. Both fractions given in doses of 15 and 40 micrograms enhanced the stereotypy induced by amphetamine. CDP I and CDP II (15 and 40 micrograms) administered 30 min before observation of the animals intensified the cataleptic action of haloperidol, whereas both fractions (CDP I and CDP II) when administered 45 min before observation reduced the catalepsy.

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