纳洛酮对清醒家兔心率、交感神经活动和主动脉压力感受器放电的影响。

Acta physiologica Polonica Pub Date : 1990-01-01
J Klawe, S Majcherczyk, M Tafil-Klawe, A Trzebski
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引用次数: 0

摘要

同时记录10只家兔的血压、心率、主动脉神经活动和颈交感放电。将电极植入未切开的主动脉和颈交感神经,进行慢性记录。1. 警报性的声音刺激产生短暂的持续的交感神经活动减少,并伴有短暂的心动过缓。2. 8只家兔中,有6只家兔静脉注射氯纳洛酮(100mg /kg)可减弱或消除声刺激引起的早期抑制作用。3.参与吃惊反应的交感抑制系统似乎独立于压力感受器抑制反射,对纳洛酮有相反的反应。4. 传出交感神经活动减少,而主动脉神经活动无变化,提示中枢压力感受器-交感-抑制性反射复位。5. 我们认为,观察到的警觉刺激后的自主神经效应是典型的恐惧-焦虑驱动。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of an alerting acoustic stimulus on the heart rate, sympathetic activity and aortic baroreceptor discharge in conscious rabbits before and after naloxone administration.

Blood pressure, heart rate, aortic nerve activity and cervical sympathetic discharge were recorded simultaneously in 10 rabbits. Chronic recordings were made with electrodes implanted to the uncut aortic and cervical sympathetic nerves. 1. The alerting acoustic stimulus produced a short lasting decrease in sympathetic activity with a transient bradycardia. 2. In 6 out of 8 rabbits i.v. administration of naloxone chloride (100 mg/kg) diminished or abolished early inhibitory effects evoked by acoustic stimulus. 3. The sympatho-inhibitory system involved in the startling response appears to be independent of the baroreceptor inhibitory reflex and has opposite responsiveness to naloxone. 4. A decrease in efferent sympathetic activity with no accompanying change in the aortic nerve activity suggests some central resetting of the baroreceptor-sympatho-inhibitory reflex. 5. We suggest that the observed autonomic effects following an alerting stimulus are typical for a fear-anxiety drive.

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