死基化:一种控制c-fos mRNA衰变的机制。

Enzyme Pub Date : 1990-01-01 DOI:10.1159/000468756
M E Greenberg, A B Shyu, J G Belasco
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引用次数: 27

摘要

c-fos原癌基因mRNA非常不稳定,在被转运到生长因子刺激的成纤维细胞的细胞质后几分钟内就会迅速降解。对控制c-fos消息衰变的结构决定因素的分析表明,该消息包含至少两个功能独立的元素,这些元素导致其半衰期短。其中一个决定因素是富含au的序列,存在于c-fos信息的3'非翻译区,而另一个决定因素,在结构上与富含au的元件无关,位于c-fos蛋白编码序列中。c-fos富au元件和编码区不稳定性决定因子似乎都是通过促进快速去除c-fos多聚(A)尾部作为mRNA降解过程的第一步而起作用的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Deadenylylation: a mechanism controlling c-fos mRNA decay.

The c-fos proto-oncogene mRNA is extremely labile and is rapidly degraded within minutes after being transported to the cytoplasm of growth factor-stimulated fibroblasts. Analysis of the structural determinants controlling c-fos message decay reveals that this message contains at least two functionally independent elements that are responsible for its short half-life. One of these determinants is an AU-rich sequence present in the 3' untranslated region of the c-fos message, whereas the other determinant, which is structurally unrelated to the AU-rich element, is located within the c-fos protein-coding sequence. Both the c-fos AU-rich element and the coding region instability determinant appear to function by facilitating rapid removal of the c-fos poly(A) tail as a first step in the mRNA degradation process.

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