LYVE-1 expression in liver cells of mice with functional pinealectomy

Motivation and Aim. An integral factor of modern life is the use of continuous artificial lighting and constant changes in light mode. As a result of the long existence of a person under such conditions, the production of the pineal gland hormone melatonin significantly decreases/stops in his body (functional pinealectomy), there is an imbalance of cyclicity in the work of body systems, desynchronosis develops. It is known that the liver is not only a unique metabolic and immunological organ, it is the largest source of lymph production in the body, and it accounts for up to 50% of the lymph entering the thoracic duct [Tanaka M. and Iwakiri Y., 2016]. It was found that under the influence of constant lighting in the liver and its lymphatic region, circulatory and lymphatic flow disorders develop. These processes lead to the development of hypoxia, which negatively affects the structure and function of the organ parenchyma cells [Michurina S.V. et al., 2008, 2018; Tanaka M. and Iwakiri Y., 2018]. The aim of this study was to evaluate the effect of 24-hour illumination (24hL) on the expression of the LIVE-1 marker (lymphatic vessel endothelial receptor-1) in liver cells of male C57Bl / 6 mice.