超声造影剂用可生物降解聚乳酸微球的研制

Proceedings of the IEEE 27th Annual Northeast Bioengineering Conference (Cat. No.01CH37201) Pub Date : 2001-03-31 DOI:10.1109/NEBC.2001.924712

D. El-Sherif, M. Wheatley

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引用次数: 2

摘要

采用改进的双乳液溶剂蒸发法制备了平均粒径为1 /spl μ m的中空/多孔聚丙交酯共乙醇酸(PLGA)微胶囊。除了具有生物相容性和可生物降解性外，这些微球还具有声学增强功能，可作为超声诊断成像的造影剂。此外，与其他超声造影剂相比，它们非常稳定，并能提供长时间的声学增强。

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Development of biodegradable PLGA microspheres for use as ultrasound contrast agents

The authors have developed a method for producing hollow/porous poly (lactide co-glycolide) (PLGA) microcapsules with a mean size of 1 /spl mu/m by a modified double emulsion, solvent evaporation technique. Besides being biocompatible and biodegradable, these microspheres exhibit acoustic enhancements that make them useful as contrast agents for diagnostic imaging using ultrasound. Moreover, they are very stable and give a prolonged acoustic enhancement, as compared to other ultrasound contrast agents.

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Proceedings of the IEEE 27th Annual Northeast Bioengineering Conference (Cat. No.01CH37201)

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